Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sp-Thymidine-5'-O-(1-thiotriphosphate) (Sp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 µM in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-α-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM.
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Description | Sp-Thymidine-5'-O-(1-thiotriphosphate) (Sp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 µM in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-α-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM. |
Synonyms | Sp-TTP-α-S |
Molecular Weight | 586.16 |
Formula | C10H13N2O13P3S.4Na |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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Sp-Thymidine-5'-O-(1-thiotriphosphate) sodium Sp-TTP-α-S inhibitor inhibit