VEGFR-2-IN-73

Name: VEGFR-2-IN-73
Brand: TargetMol
SKU: T213354
Rating: 4.5 (1 reviews)

Catalog No. T213354 Copy Product Info

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VEGFR-2-IN-73 is a potent and highly selective inhibitor of VEGFR-2, demonstrating significantly stronger inhibition (IC50 = 0.0787 μM) compared to its effect on EGFR (IC50 = 1.31 μM). It exhibits strong antiproliferative activity across various cancer cell lines, induces cell cycle arrest at the G2/M and Pre-G1 phases, and significantly promotes apoptosis. This compound is applicable in cancer research, including studies on colorectal cancer, hepatocellular carcinoma, and breast cancer.

VEGFR-2-IN-73

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Catalog No. T213354

VEGFR-2-IN-73

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	VEGFR-2-IN-73 is a potent and highly selective inhibitor of VEGFR-2, demonstrating significantly stronger inhibition (IC50 = 0.0787 μM) compared to its effect on EGFR (IC50 = 1.31 μM). It exhibits strong antiproliferative activity across various cancer cell lines, induces cell cycle arrest at the G2/M and Pre-G1 phases, and significantly promotes apoptosis. This compound is applicable in cancer research, including studies on colorectal cancer, hepatocellular carcinoma, and breast cancer.
Targets&IC50	VEGFR2:0.0787 μM
In vitro	VEGFR-2-IN-73 (compound 15) (2 days) demonstrates significant cytotoxicity against HCT-116, HepG-2, and MCF-7 cancer cell lines with IC₅₀ values of 3.66, 3.31, and 4.29 μM respectively, while exhibiting minimal cytotoxicity towards normal WI-38 cells (IC₅₀ > 69 μM), indicating strong selectivity. It effectively induces G2/M and Pre-G1 phase cell cycle arrest and significantly triggers apoptosis in HCT-116, HepG-2, and MCF-7 cells, with effects comparable to Doxorubicin. The predicted binding energy of VEGFR-2-IN-73 with VEGFR-2 is -24.27 kcal/mol, notably lower than that of Sorafenib at -20.88 kcal/mol, suggesting superior binding affinity.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc