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CT-996 (Synonyms: RO-7795081, RO7795081, RO 7795081, RG-6652, RG6652, RG 6652)

Name: CT-996
Brand: TargetMol
SKU: T212826
Price: 135 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T212826 Copy Product Info

Purity: 99.88%

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CT-996 is an orally active GLP-1 receptor agonist that exhibits preferential cAMP signaling and reduces endocytosis. Oral administration of CT-996 improves glycemic control and reduces body weight and body fat.

CT-996

Copy Product Info

🥰Excellent

Catalog No. T212826

Synonyms RO-7795081, RO7795081, RO 7795081, RG-6652, RG6652, RG 6652

Cas No. 2810808-95-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$135	-	In Stock
5 mg	$298	-	In Stock
10 mg	$481	-	In Stock
25 mg	$962	-	In Stock
50 mg	$1,550	-	In Stock
100 mg	$2,470	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.88%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CT-996 is an orally active GLP-1 receptor agonist that exhibits preferential cAMP signaling and reduces endocytosis. Oral administration of CT-996 improves glycemic control and reduces body weight and body fat.
Targets&IC50	GLP1 receptor:0.49 nM (EC50)
In vitro	In vitro experiments show that CT-996 has the same effect in stimulating the accumulation of cAMP in cells expressing human or macaque GLP-1R, and can stimulate the insulin secretion of human β cell line. Compared with natural GLP-1, CT-996 has little effect on the recruitment of β- arrestin, and the internalization of GLP-1R is weak.
In vivo	In vivo, a single oral administration of CT-996 can effectively inhibit the postprandial blood glucose level of mice expressing human GLP-1 receptor after mixed meal tolerance test (MMTT), and enhance glucose-stimulated insulin secretion (GSIS) in obese monkeys. In a 4-week study on obese monkeys, daily administration of CT-996 significantly inhibited the fluctuation of plasma glucose and insulin during MMTT. Compared with the control group, CT-996 significantly reduced food intake, body weight and fat mass. All doses were well tolerated.
Synonyms	RO-7795081, RO7795081, RO 7795081, RG-6652, RG6652, RG 6652

Chemical Properties

Molecular Weight	579.59
Formula	C₃₀H₃₁F₂N₅O₅
Cas No.	2810808-95-6
Smiles	C(N1C=2C(N=C1CN3[C@@H](C)C[C@@H](OC4=NC(COC5=C(F)C=C(F)C=C5)=NC=C4)CC3)=CC=C(C(O)=O)C2)[C@@H]6CCO6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100.00 mg/mL (172.54 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7254 mL	8.6268 mL	17.2536 mL	86.2679 mL
5 mM	0.3451 mL	1.7254 mL	3.4507 mL	17.2536 mL
10 mM	0.1725 mL	0.8627 mL	1.7254 mL	8.6268 mL
20 mM	0.0863 mL	0.4313 mL	0.8627 mL	4.3134 mL
50 mM	0.0345 mL	0.1725 mL	0.3451 mL	1.7254 mL
100 mM	0.0173 mL	0.0863 mL	0.1725 mL	0.8627 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc