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TCID

🥰Excellent
Catalog No. T6697Cas No. 30675-13-9
Alias UCH-L3 Inhibitor

TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.

TCID

TCID

🥰Excellent
Purity: 99.34%
Catalog No. T6697Alias UCH-L3 InhibitorCas No. 30675-13-9
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$52In StockIn Stock
10 mg$80In StockIn Stock
25 mg$178In StockIn Stock
50 mg$231In StockIn Stock
100 mg$300In StockIn Stock
1 mL x 10 mM (in DMSO)$56In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.34%
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Product Introduction

Bioactivity
Description
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
Targets&IC50
UCHL3:0.6 μM
In vitro
TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3]
SynonymsUCH-L3 Inhibitor
Chemical Properties
Molecular Weight283.92
FormulaC9H2Cl4O2
Cas No.30675-13-9
SmilesClc1c2C(=O)CC(=O)c2c(Cl)c(Cl)c1Cl
Relative Density.1.782g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 14.2 mg/mL (50.01 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.04 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5221 mL17.6106 mL35.2212 mL176.1059 mL
5 mM0.7044 mL3.5221 mL7.0442 mL35.2212 mL
10 mM0.3522 mL1.7611 mL3.5221 mL17.6106 mL
20 mM0.1761 mL0.8805 mL1.7611 mL8.8053 mL
50 mM0.0704 mL0.3522 mL0.7044 mL3.5221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UCH-L3UCH-L1ubiquitinationubiquitintransporterTCIDNeuronalInhibitorinhibithydrolaseGlyT2glycineDUBsDeubiquitinaseC-terminal
Related Tags: buy TCID | purchase TCID | TCID cost | order TCID | TCID chemical structure | TCID in vitro | TCID formula | TCID molecular weight
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