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L748337

Name: L748337
Brand: TargetMol
SKU: T22905
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22905Cas No. 244192-94-7

Alias L-748,337

L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors.

L748337

😃Good

Purity: 99.67%

Catalog No. T22905Alias L-748,337Cas No. 244192-94-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$63	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors.
Targets&IC50	β3-adrenoceptor:4 nM (Ki), β2-adrenoceptor:204 nM (Ki), β1-adrenoceptor:390 nM (Ki)
In vitro	The β3-adrenergic receptor selective antagonist L748337 (100nM) partially antagonized the relaxation induced by (-)-isoprenaline in cav-1KO arteries, but did not antagonize the relaxation in WT arteries[1].
In vivo	L748337 (5 mg/kg) exhibits anti-cancer effects in male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cells[1].
Synonyms	L-748,337

Chemical Properties

Molecular Weight	497.61
Formula	C₂₆H₃₁N₃O₅S
Cas No.	244192-94-7
Smiles	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)c3ccccc3)cc2)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (40.19 mM), Sonication is recommended.

DMSO: 80 mg/mL (160.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0096 mL	10.0480 mL	20.0961 mL	100.4803 mL
5 mM	0.4019 mL	2.0096 mL	4.0192 mL	20.0961 mL
10 mM	0.2010 mL	1.0048 mL	2.0096 mL	10.0480 mL
20 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0240 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0096 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc