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L748337

Name: L748337
Brand: TargetMol
SKU: T22905
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22905Cas No. 244192-94-7

Alias L-748,337

L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors.

L748337

🥰Excellent

Purity: 99.67%

Catalog No. T22905Alias L-748,337Cas No. 244192-94-7

Pack Size	Price	Availability	Quantity
1 mg	$63	In Stock

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Purity:99.67%

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Product Introduction

Bioactivity

Description	L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors.
Targets&IC50	β2-adrenoceptor:204 nM (Ki), β1-adrenoceptor:390 nM (Ki), β3-adrenoceptor:4 nM (Ki)
In vitro	The β3-adrenergic receptor selective antagonist L748337 (100nM) partially antagonized the relaxation induced by (-)-isoprenaline in cav-1KO arteries, but did not antagonize the relaxation in WT arteries[1].
In vivo	L748337 (5 mg/kg) exhibits anti-cancer effects in male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cells[1].
Synonyms	L-748,337

Chemical Properties

Molecular Weight	497.61
Formula	C₂₆H₃₁N₃O₅S
Cas No.	244192-94-7
Smiles	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)c3ccccc3)cc2)c1
Relative Density.	no data available
Color	Yellow
Appearance	Oil

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (160.77 mM), Sonication is recommended.

Ethanol: 20 mg/mL (40.19 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0096 mL	10.0480 mL	20.0961 mL	100.4803 mL
5 mM	0.4019 mL	2.0096 mL	4.0192 mL	20.0961 mL
10 mM	0.2010 mL	1.0048 mL	2.0096 mL	10.0480 mL
20 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0240 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0096 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc