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LTURM34

Name: LTURM34
Brand: TargetMol
SKU: T15789
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15789Cas No. 1879887-96-3

LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .

LTURM34

🥰Excellent

Purity: 99.34%

Catalog No. T15789Cas No. 1879887-96-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$257	In Stock	In Stock
100 mg	$383	-	In Stock
200 mg	$560	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
Targets&IC50	PI3Kβ:5.8 μM, DNA-PK:34 nM, PI4Kδ:8.5 μM
In vitro	LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .

Chemical Properties

Molecular Weight	414.48
Formula	C₂₄H₁₈N₂O₃S
Cas No.	1879887-96-3
Smiles	O=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (144.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4127 mL	12.0633 mL	24.1266 mL	120.6331 mL
5 mM	0.4825 mL	2.4127 mL	4.8253 mL	24.1266 mL
10 mM	0.2413 mL	1.2063 mL	2.4127 mL	12.0633 mL
20 mM	0.1206 mL	0.6032 mL	1.2063 mL	6.0317 mL
50 mM	0.0483 mL	0.2413 mL	0.4825 mL	2.4127 mL
100 mM	0.0241 mL	0.1206 mL	0.2413 mL	1.2063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc