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Anti-FLT3 Antibody-APC (2N391)
🥰Excellent
Catalog No. TMAY-00840A
Anti-FLT3 Antibody-APC (2N391) is a APC-conjugated Mouse antibody targeting FLT3. Anti-FLT3 Antibody-APC (2N391) can be used in FCM.
Anti-FLT3 Antibody-APC (2N391)
Anti-FLT3 Antibody-APC (2N391)
🥰Excellent
Catalog No. TMAY-00840A
Anti-FLT3 Antibody-APC (2N391) is a APC-conjugated Mouse antibody targeting FLT3. Anti-FLT3 Antibody-APC (2N391) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-FLT3 Antibody-APC (2N391) is a APC-conjugated Mouse antibody targeting FLT3. Anti-FLT3 Antibody-APC (2N391) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2N391 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-human CD135 on human whole blood monocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FLT3 / CD135 / FLK2 (rh FLT3 / CD135 / FLK2; TMPY-01247; P36888-1; Met1-Asn541,T227M) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD135, also known as FLT-3, FLK-2, is a member of the CD system. CD135 is an important cell surface marker recognized by specific sets of antibodies to identify the types of hematopoietic (blood) progenitors in the bone marrow and it function to differentiate hematopoietic stem cells, which are CD135 negative, from multipotent progenitors, which are CD135 positive. CD135 is a receptor tyrosine kinase typeⅢ for the cytokine Flt3 ligand and activat signaling through second messengers by binding to Flt3. Signaling through CD135 is important for lymphocyte development. The encoding gene CD135 is a proto-oncogene to which mutations happened will lead to cancer such as leukemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human FLT3 / CD135 / FLK2 protein (TMPY-01247) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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