SW2_110A acetate

Name: SW2_110A acetate
Brand: TargetMol
SKU: T36798L
Rating: 4.5 (1 reviews)

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Catalog No. T36798L

SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells.

SW2_110A acetate

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Catalog No. T36798L

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$157	Inquiry	Inquiry
5 mg	$318	Inquiry	Inquiry
10 mg	$527	Inquiry	Inquiry
25 mg	$995	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells.
Targets&IC50	CBX8 ChD:800 nM(Kd)
In vitro	SW2_110A exhibits selective inhibition of the binding between CBX8 and chromatin within cells, thereby effectively suppressing the proliferation of THP1 leukemia cells fueled by the MLL-AF9 translocation, with an IC50 value of 26 µM. Treatment of THP1 cells with SW2_110A leads to a notable reduction in the expression of MLL-AF9 target genes, including HOXA9.[1]

Chemical Properties

Molecular Weight	821.01
Formula	C₄₄H₆₄N₆O₉
Smiles	CCN(CCCC[C@H](NC([C@H](NC([C@H](C1CCCC1)NC(C2=CC=C(OC3=CC=CC=C3)C=C2)=O)=O)[C@@H](C)CC)=O)C(N[C@@H](CO)C(NCC#C)=O)=O)CC.CC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc