store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 157.00 | |
5 mg | Inquiry | $ 318.00 | |
10 mg | Inquiry | $ 527.00 | |
25 mg | Inquiry | $ 995.00 |
Description | SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells. |
Targets&IC50 | CBX8 ChD:800 nM(Kd) |
In vitro | SW2_110A exhibits selective inhibition of the binding between CBX8 and chromatin within cells, thereby effectively suppressing the proliferation of THP1 leukemia cells fueled by the MLL-AF9 translocation, with an IC50 value of 26 µM. Treatment of THP1 cells with SW2_110A leads to a notable reduction in the expression of MLL-AF9 target genes, including HOXA9.[1] |
Molecular Weight | 821.01 |
Formula | C44H64N6O9 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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SW2_110A acetate Chromatin/Epigenetic Histone Methyltransferase SW2_110Aacetate SW2_110A Acetate inhibitor inhibit