Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compound specifically induces reactive oxygen species (ROS) generation, demonstrating antitumor efficacy [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compound specifically induces reactive oxygen species (ROS) generation, demonstrating antitumor efficacy [1]. |
In vitro | MitoCur-1 exhibits selective cytotoxicity to HepG2 and L02 cells, with IC50 values of 1.4 μM and 9.1 μM, respectively [1]. At a concentration of 10 μM for 12 hours, MitoCur-1 induces ROS production and selectively depletes GSH in HepG2 cells [1]. Furthermore, MitoCur-1 (10 μM; 24 h) arrests the cell cycle at the G0/G1 phase and inhibits the expression of cell cycle proteins in HepG2 cells [1]. |
In vivo | MitoCur-1, administered intraperitoneally at doses of 5 mg/kg and 15 mg/kg on an every-other-day schedule for a total of four weeks, suppressed tumor growth in a murine model without affecting body weight [1]. |
Molecular Weight | 1074.05 |
Formula | C65H64Cl2O6P2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MitoCur-1 Others inhibitor inhibit