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Hydroxyfasudil

Name: Hydroxyfasudil
Brand: TargetMol
SKU: T4276L
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4276LCas No. 105628-72-6

Alias Hydroxy-Fasudil, HA-1100

Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).

Hydroxyfasudil

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Purity: 98.13%

Catalog No. T4276LAlias Hydroxy-Fasudil, HA-1100Cas No. 105628-72-6

Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).

Pack Size	Price	Availability
5 mg	$34	In Stock
10 mg	$51	In Stock
25 mg	$95	In Stock
50 mg	$155	In Stock
100 mg	$245	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock

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Batch Information

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Purity:98.13%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
Targets&IC50	PKA:37 μM, ROCK1:0.73 μM, ROCK2:0.72 μM
Synonyms	Hydroxy-Fasudil, HA-1100

Chemical Properties

Molecular Weight	307.37
Formula	C₁₄H₁₇N₃O₃S
Cas No.	105628-72-6
Smiles	O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1
Relative Density.	1.329g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31 mg/mL (100.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2534 mL	16.2670 mL	32.5341 mL	162.6704 mL
5 mM	0.6507 mL	3.2534 mL	6.5068 mL	32.5341 mL
10 mM	0.3253 mL	1.6267 mL	3.2534 mL	16.2670 mL
20 mM	0.1627 mL	0.8134 mL	1.6267 mL	8.1335 mL
50 mM	0.0651 mL	0.3253 mL	0.6507 mL	3.2534 mL
100 mM	0.0325 mL	0.1627 mL	0.3253 mL	1.6267 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc