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(R)-(-)-JQ1 Enantiomer

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Catalog No. T19618Cas No. 1268524-71-5

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.

(R)-(-)-JQ1 Enantiomer
Other Forms of (R)-(-)-JQ1 Enantiomer:

(R)-(-)-JQ1 Enantiomer

🥰Excellent
Purity: 99.38%
Catalog No. T19618Cas No. 1268524-71-5
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$42In StockIn Stock
10 mg$60In StockIn Stock
25 mg$98In StockIn Stock
50 mg$143In StockIn Stock
100 mg$213In StockIn Stock
200 mg$317-In Stock
1 mL x 10 mM (in DMSO)$48In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.38%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.
Chemical Properties
Molecular Weight456.99
FormulaC23H25ClN4O2S
Cas No.1268524-71-5
SmilesCc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Relative Density.1.33 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (196.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.22 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1882 mL10.9412 mL21.8823 mL109.4116 mL
5 mM0.4376 mL2.1882 mL4.3765 mL21.8823 mL
10 mM0.2188 mL1.0941 mL2.1882 mL10.9412 mL
20 mM0.1094 mL0.5471 mL1.0941 mL5.4706 mL
50 mM0.0438 mL0.2188 mL0.4376 mL2.1882 mL
100 mM0.0219 mL0.1094 mL0.2188 mL1.0941 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

JQ1 EnantiomerInhibitorinhibitEpigeneticReaderDomainEpigenetic Reader DomainBET bromodomain(R)-(-)-JQ-1 Enantiomer(R)()JQ1 Enantiomer(R) ( ) JQ1 Enantiomer
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