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(R)-(-)-JQ1 Enantiomer

Name: (R)-(-)-JQ1 Enantiomer
Brand: TargetMol
SKU: T19618
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19618Cas No. 1268524-71-5

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.

(R)-(-)-JQ1 Enantiomer

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Purity: 99.38%

Catalog No. T19618Cas No. 1268524-71-5

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$60	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$143	In Stock	In Stock
100 mg	$213	In Stock	In Stock
200 mg	$317	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

(R)-(-)-JQ1 Enantiomer AI Summary

(R)-(-)-JQ1 Enantiomer exhibits bioactivity as an inhibitor of human BRD4 bromodomains 1 and 2 with IC50 values of 77.0 nM and 33.0 nM, respectively, as determined using the AlphaScreen assay method with H4K5acK8acK12acK16ac as the substrate. It also shows a dissociation constant (Kd) of 49.0 nM for BRD4 bromodomain 1. Despite these strong inhibitory activities, some assays report no significant inhibition on BRD4 bromodomain 1 and 2 interactions with acetylated histone H4, with IC50 values exceeding 10,000,000 nM. Additionally, the compound displays cell-specific effects on viability, demonstrating growth rates ranging from inhibitory to stimulatory across different cell types such as HEK293T, U2OS, and human fibroblast cells. Further observations from the Thermal Shift Assay indicate varying impacts on protein domain stability, as evidenced by both positive and negative changes in melting temperature across different domains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, a BET bromodomain inhibitor, which acts on BRD4(1/2) with IC50 values of 77 nM and 33 nM in a cell-free assay.

Chemical Properties

Molecular Weight	456.99
Formula	C₂₃H₂₅ClN₄O₂S
Cas No.	1268524-71-5
Smiles	Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Relative Density.	1.33 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (196.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1882 mL	10.9412 mL	21.8823 mL	109.4116 mL
5 mM	0.4376 mL	2.1882 mL	4.3765 mL	21.8823 mL
10 mM	0.2188 mL	1.0941 mL	2.1882 mL	10.9412 mL
20 mM	0.1094 mL	0.5471 mL	1.0941 mL	5.4706 mL
50 mM	0.0438 mL	0.2188 mL	0.4376 mL	2.1882 mL
100 mM	0.0219 mL	0.1094 mL	0.2188 mL	1.0941 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc