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BVT-14225

Name: BVT-14225
Brand: TargetMol
SKU: T3542
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3542Cas No. 376638-65-2

Alias BVT 14225

BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.

BVT-14225

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Purity: 98.34%

Catalog No. T3542Alias BVT 14225Cas No. 376638-65-2

BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$54	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$145	In Stock	In Stock
25 mg	$267	In Stock	In Stock
50 mg	$433	In Stock	In Stock
100 mg	$642	-	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.34%

Appearance:Solid

Color:Red

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.
Targets&IC50	11β-HSD1:52 nM
In vitro	BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.
Synonyms	BVT 14225

Chemical Properties

Molecular Weight	401.93
Formula	C₁₆H₂₀ClN₃O₃S₂
Cas No.	376638-65-2
Smiles	CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1
Relative Density.	1.373 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4880 mL	12.4400 mL	24.8800 mL	124.3998 mL
5 mM	0.4976 mL	2.4880 mL	4.9760 mL	24.8800 mL
10 mM	0.2488 mL	1.2440 mL	2.4880 mL	12.4400 mL
20 mM	0.1244 mL	0.6220 mL	1.2440 mL	6.2200 mL
50 mM	0.0498 mL	0.2488 mL	0.4976 mL	2.4880 mL
100 mM	0.0249 mL	0.1244 mL	0.2488 mL	1.2440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc