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BVT-14225

Name: BVT-14225
Brand: TargetMol
SKU: T3542
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3542Cas No. 376638-65-2

Alias BVT 14225

BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.

BVT-14225

🥰Excellent

Purity: 97.78%

Catalog No. T3542Alias BVT 14225Cas No. 376638-65-2

BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.

Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$54	In Stock
5 mg	$97	In Stock
10 mg	$145	In Stock
25 mg	$267	In Stock
50 mg	$433	In Stock
100 mg	$642	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Batch Information

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Purity:97.78%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BVT-14225, a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, has an IC50 value of 52 nM.
Targets&IC50	11β-HSD1:52 nM
In vitro	BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.
Synonyms	BVT 14225

Chemical Properties

Molecular Weight	401.93
Formula	C₁₆H₂₀ClN₃O₃S₂
Cas No.	376638-65-2
Smiles	CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1
Relative Density.	1.373 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4880 mL	12.4400 mL	24.8800 mL	124.3998 mL
5 mM	0.4976 mL	2.4880 mL	4.9760 mL	24.8800 mL
10 mM	0.2488 mL	1.2440 mL	2.4880 mL	12.4400 mL
20 mM	0.1244 mL	0.6220 mL	1.2440 mL	6.2200 mL
50 mM	0.0498 mL	0.2488 mL	0.4976 mL	2.4880 mL
100 mM	0.0249 mL	0.1244 mL	0.2488 mL	1.2440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc