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RS 23597-190 hydrochloride (Synonyms: RS 23597-190, EP-A-501322)

Name: RS 23597-190 hydrochloride
Brand: TargetMol
SKU: T23255
Rating: 4.5 (1 reviews)

Catalog No. T23255 Copy Product Info

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RS 23597-190 hydrochloride is an indole derivative and a potent, selective 5-HT4 receptor antagonist (pKi = 9.1). It acts by blocking 5-HT4-mediated cAMP accumulation with high selectivity, used for gastrointestinal motility and arrhythmia research.

RS 23597-190 hydrochloride

Copy Product Info

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Catalog No. T23255

Synonyms RS 23597-190, EP-A-501322

Cas No. 149719-06-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$30	6-8 weeks	6-8 weeks
5 mg	$56	6-8 weeks	6-8 weeks
10 mg	$98	35 days	35 days
25 mg	$215	6-8 weeks	6-8 weeks
50 mg	$379	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$59	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	RS 23597-190 hydrochloride is an indole derivative and a potent, selective 5-HT4 receptor antagonist (pKi = 9.1). It acts by blocking 5-HT4-mediated cAMP accumulation with high selectivity, used for gastrointestinal motility and arrhythmia research.
Synonyms	RS 23597-190, EP-A-501322

Chemical Properties

Molecular Weight	363.28
Formula	C₁₆H₂₄Cl₂N₂O₃
Cas No.	149719-06-2
Smiles	Cl.O=C(OCCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (220.22 mM), Sonication is recommmended.

H2O: 4 mg/mL (11.01 mM), Sonication is recommmended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7527 mL	13.7635 mL	27.5270 mL	137.6349 mL
5 mM	0.5505 mL	2.7527 mL	5.5054 mL	27.5270 mL
10 mM	0.2753 mL	1.3763 mL	2.7527 mL	13.7635 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1376 mL	0.6882 mL	1.3763 mL	6.8817 mL
50 mM	0.0551 mL	0.2753 mL	0.5505 mL	2.7527 mL
100 mM	0.0275 mL	0.1376 mL	0.2753 mL	1.3763 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc