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U93631

Name: U93631
Brand: TargetMol
SKU: T3644
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3644Cas No. 152273-12-6

GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.

U93631

🥰Excellent

Purity: 99.76%

Catalog No. T3644Cas No. 152273-12-6

Pack Size	Price	Availability
25 mg	$45	In Stock
50 mg	$68	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.76%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
Targets&IC50	GABAA:100 nM
In vitro	In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization, rather than acting as an open channel blocker.

Chemical Properties

Molecular Weight	299.37
Formula	C₁₇H₂₁N₃O₂
Cas No.	152273-12-6
Smiles	CC(C)(C)OC(=O)c1ncn-2c1C(C)(C)Nc1ccccc-21
Relative Density.	1.19g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (183.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3403 mL	16.7017 mL	33.4035 mL	167.0174 mL
5 mM	0.6681 mL	3.3403 mL	6.6807 mL	33.4035 mL
10 mM	0.3340 mL	1.6702 mL	3.3403 mL	16.7017 mL
20 mM	0.1670 mL	0.8351 mL	1.6702 mL	8.3509 mL
50 mM	0.0668 mL	0.3340 mL	0.6681 mL	3.3403 mL
100 mM	0.0334 mL	0.1670 mL	0.3340 mL	1.6702 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc