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CDK9 inhibitor HH1

Name: CDK9 inhibitor HH1
Brand: TargetMol
SKU: T118066
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T118066Cas No. 204188-41-0

Alias 8019-9719

CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.

CDK9 inhibitor HH1

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Purity: 99.92%

Catalog No. T118066Alias 8019-9719Cas No. 204188-41-0

CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$50	In Stock	In Stock
50 mg	$74	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

CDK9 inhibitor HH1 AI Summary

CDK9 inhibitor HH1 inhibits human CDK2/Cyclin A2 with an IC50 value of 2000.0 nM, indicating its potential in suppressing the activity of this enzyme complex that is crucial for cell cycle regulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.
Synonyms	8019-9719

Chemical Properties

Molecular Weight	261.34
Formula	C₁₃H₁₅N₃OS
Cas No.	204188-41-0
Smiles	CC(C)NC1=NC(N)=C(S1)C(=O)C1=CC=CC=C1
Relative Density.	1.272 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (191.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8264 mL	19.1322 mL	38.2643 mL	191.3216 mL
5 mM	0.7653 mL	3.8264 mL	7.6529 mL	38.2643 mL
10 mM	0.3826 mL	1.9132 mL	3.8264 mL	19.1322 mL
20 mM	0.1913 mL	0.9566 mL	1.9132 mL	9.5661 mL
50 mM	0.0765 mL	0.3826 mL	0.7653 mL	3.8264 mL
100 mM	0.0383 mL	0.1913 mL	0.3826 mL	1.9132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc