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Anti-DcR2/TRAIL R4 Antibody (5W924)
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Catalog No. TMAY-00787
Alias tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain, TRUNDD, TRAIL-R4, TRAILR4, DCR2, CD264
Anti-DcR2/TRAIL R4 Antibody (5W924) is a Rabbit antibody targeting DcR2/TRAIL R4. Anti-DcR2/TRAIL R4 Antibody (5W924) can be used in IHC-P.
Anti-DcR2/TRAIL R4 Antibody (5W924)
Anti-DcR2/TRAIL R4 Antibody (5W924)
😃Good
Catalog No. TMAY-00787Alias tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain, TRUNDD, TRAIL-R4, TRAILR4, DCR2, CD264
Anti-DcR2/TRAIL R4 Antibody (5W924) is a Rabbit antibody targeting DcR2/TRAIL R4. Anti-DcR2/TRAIL R4 Antibody (5W924) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P Reactivity: Human |
| Alias | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain, TRUNDD, TRAIL-R4, TRAILR4, DCR2, CD264 |
| Ig Type | Rabbit IgG |
| Clone | 5W924 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human TNFRSF10D in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to trophocyte. 2. Immunochemical staining of human TNFRSF10D in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to kidney tubules and colleting duct. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R4 / CD264 / TNFRSF10D (rh TRAIL R4 / CD264 / TNFRSF10D; TMPY-01381; NP_003831.2; Met1-His211). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human TRAIL R4 / CD264 / TNFRSF10D protein (TMPY-01381) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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