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PROTAC CBP/P300 Degrader-1

Catalog No. T40143 CAS 2484739-48-0

Synonyms: PROTAC CBP/P300 Degrader-1

PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PROTAC CBP/P300 Degrader-1 Chemical Structure

PROTAC CBP/P300 Degrader-1, CAS 2484739-48-0

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 872.00
10 mg	Inquiry	$ 1,360.00
50 mg	Inquiry	Inquiry
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Biological Description

Chemical Properties

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Description

PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.

In vitro

PROTAC CBP/P300 Degrader-1 shows LNCaP prostate cancer cell viability inhibition (IC 50 =0.4 nM). PROTAC CBP/P300 Degrader-1 (10 nM) induces degradation of P300 (≥ 80%)[1]. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancel cell lines (IC 50 s ranging from 0.1-141.4 nM for HEL, NOMO-1, MOLM-13, HL-60, MEG-01, MM.IS, MM.1R, NCL-H929, RPM-8226, AMO-1, WSU-DLCL2, Karpas-422, Pfeiffer, SU-DHL-1, LNCap clone FGC, VCap; 22RV1, NCI-H520, NCI-H703, LK-2, MCE-7, and SK-BR-3 cells)[1].

Synonyms	PROTAC CBP/P300 Degrader-1
Molecular Weight	893.998
Formula	C46H53F2N11O6
CAS No.	2484739-48-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PROTAC CBP/P300 Degrader-1 2484739-48-0 PROTAC CBP/P300 Degrader1 PROTAC CBP/P300 Degrader 1 PROTAC CBP/P-300 Degrader-1 inhibitor inhibit

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