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POSH-IN-1

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Catalog No. T200931Cas No. 328960-84-5

POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (a ubiquitin ligase/E3 enzyme) with an IC50 = 900 nM and has antiviral, anticancer, and neurodegenerative disease potential.

POSH-IN-1

POSH-IN-1

🥰Excellent
Catalog No. T200931Cas No. 328960-84-5
POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (a ubiquitin ligase/E3 enzyme) with an IC50 = 900 nM and has antiviral, anticancer, and neurodegenerative disease potential.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$65In Stock
10 mg$95In Stock
25 mg$157In Stock
50 mg$233In Stock
100 mg$347In Stock
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Product Introduction

Bioactivity
Description
POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (a ubiquitin ligase/E3 enzyme) with an IC50 = 900 nM and has antiviral, anticancer, and neurodegenerative disease potential.
Targets&IC50
POSH:900 nM
In vitro
POSH-IN-1(compound 108) inhibited the ubiquitin ligase activity of POSH with an IC₅₀ of 900 nM[1].
Chemical Properties
Molecular Weight289.28
FormulaC14H8FNO3S
Cas No.328960-84-5
SmilesO=C1SC(=CC=2OC(=CC2)C=3C=CC(F)=CC3)C(=O)N1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (138.27 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4569 mL17.2843 mL34.5686 mL172.8429 mL
5 mM0.6914 mL3.4569 mL6.9137 mL34.5686 mL
10 mM0.3457 mL1.7284 mL3.4569 mL17.2843 mL
20 mM0.1728 mL0.8642 mL1.7284 mL8.6421 mL
50 mM0.0691 mL0.3457 mL0.6914 mL3.4569 mL
100 mM0.0346 mL0.1728 mL0.3457 mL1.7284 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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