Shopping Cart

Your shopping cart is currently empty

Propafenone

Name: Propafenone
Brand: TargetMol
SKU: T0866
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Rythmol, Propafenonum) Copy Product Info

🥰Excellent

Synonyms: Rythmol, Propafenonum

Catalog No. T0866 Copy Product Info

Purity: 99.02%

🥰Excellent

Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.

Cas No. 54063-53-5

Pack Size	Price	USA Stock	Global Stock
25 mg	$39	In Stock	In Stock
50 mg	$64	In Stock	In Stock
100 mg	$105	In Stock	In Stock
200 mg	$155	In Stock	In Stock
500 mg	$262	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.02%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Synonyms

Rythmol, Propafenonum

Chemical Properties

Molecular Weight	341.44
Formula	C₂₁H₂₇NO₃
Cas No.	54063-53-5
Smiles	O(CC(CNCCC)O)C1=C(C(CCC2=CC=CC=C2)=O)C=CC=C1
Relative Density.	1.096 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 5 mg/mL (14.64 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9288 mL	14.6439 mL	29.2877 mL	146.4386 mL
5 mM	0.5858 mL	2.9288 mL	5.8575 mL	29.2877 mL
10 mM	0.2929 mL	1.4644 mL	2.9288 mL	14.6439 mL
20 mM	0.1464 mL	0.7322 mL	1.4644 mL	7.3219 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	2.9288 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4644 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Propafenone chemical structure | Propafenone formula | Propafenone molecular weight