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SR 1903 (Synonyms: SR-1903, SR1903)

Name: SR 1903
Brand: TargetMol
SKU: T35638
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T35638 Copy Product Info

Purity: 99.93%

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SR 1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ = 100 nM and 209 nM, respectively) and an agonist of LXR (EC₅₀ = 154 nM). It exerts anti-inflammatory and anti-diabetic effects in mouse models of collagen-induced arthritis and diet-induced obesity.

SR 1903

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Catalog No. T35638

Synonyms SR-1903, SR1903

Cas No. 1414248-06-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$133	-	In Stock
5 mg	$485	-	In Stock
10 mg	$885	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SR 1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ = 100 nM and 209 nM, respectively) and an agonist of LXR (EC₅₀ = 154 nM). It exerts anti-inflammatory and anti-diabetic effects in mouse models of collagen-induced arthritis and diet-induced obesity.
Targets&IC50	RORγ:~100 nM, RORγ:209 nM, LXR:154 nM (EC50)
In vitro	Methods: Macrophages were used as the research object, pretreated with 10 μM SR 1903, and stimulated with LPS. Results: SR 1903 attenuated the LPS signaling pathway and inhibited TREM-1 gene expression. Methods: RAW264.7 macrophages were used as the model and treated with SR 1903. Results: SR 1903 upregulated the expression of LXR target genes, including cholesterol efflux-related genes (ABCG1, SCD) and lipid metabolism-related genes (ACACA, FASN) [1].
In vivo	Methods: Collagen-induced arthritis (CIA) mice were intraperitoneally injected with SR 1903 (20 mg/kg, twice daily for 16 days). Results: SR 1903 ameliorated arthritis symptoms and prevented thymocyte loss in mice [1]. Methods: Diet-induced obese (DIO) mice were intraperitoneally injected with SR 1903 (20 mg/kg for 14 consecutive days). Results: SR 1903 improved metabolic parameters and exerted protective effects against obesity-associated thymic involution in mice [1].
Synonyms	SR-1903, SR1903

Chemical Properties

Molecular Weight	523.51
Formula	C₂₇H₂₇F₆N₃O
Cas No.	1414248-06-8
Smiles	FC(F)(F)C(O)(C1=CC=C(C=C1)C=2C=CC(=CC2C)CN3CCN(CC=4C=CN=CC4)CC3)C(F)(F)F
Relative Density.	1.307 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (19.1 mM), Sonication is recommended.

DMF: 10 mg/mL (19.1 mM), Sonication is recommended.

Ethanol: 5 mg/mL (9.55 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	1.9102 mL	9.5509 mL	19.1018 mL	95.5092 mL
5 mM	0.3820 mL	1.9102 mL	3.8204 mL	19.1018 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
10 mM	0.1910 mL	0.9551 mL	1.9102 mL	9.5509 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc