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CRTh2 antagonist 1

Name: CRTh2 antagonist 1
Brand: TargetMol
SKU: T10084
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10084Cas No. 1379445-54-1

CRTh2 antagonist 1 is a CRTh2 antagonist [IC50: 89 nM].

CRTh2 antagonist 1

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Purity: 97.24%

Catalog No. T10084Cas No. 1379445-54-1

CRTh2 antagonist 1 is a CRTh2 antagonist [IC50: 89 nM].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$394	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
500 mg	$2,260	-	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.24%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

CRTh2 antagonist 1 AI Summary

CRTh2 antagonist 1 exhibits inhibition of thromboxane A2 receptor and DP1 receptor at 10 µM relative to control, with an inhibition of less than 40.0%. Additionally, it shows antagonist activity at the CRTh2 receptor, overexpressed in CHOK1 cell membranes, with an IC50 of 89.0 nM in inhibiting [35S]-GTPγS binding..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CRTh2 antagonist 1 is a CRTh2 antagonist [IC50: 89 nM].
Targets&IC50	CRTH2:89 nM

Chemical Properties

Molecular Weight	455.53
Formula	C₂₃H₂₅N₃O₅S
Cas No.	1379445-54-1
Smiles	C(C(O)=O)C=1C(=NN(CC2=C(S(=O)(=O)N3CCOCC3)C=CC=C2)C1C)C4=CC=CC=C4
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (120.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1952 mL	10.9762 mL	21.9525 mL	109.7623 mL
5 mM	0.4390 mL	2.1952 mL	4.3905 mL	21.9525 mL
10 mM	0.2195 mL	1.0976 mL	2.1952 mL	10.9762 mL
20 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4881 mL
50 mM	0.0439 mL	0.2195 mL	0.4390 mL	2.1952 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc