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Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2
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Catalog No. TMAC-01933
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2
😃Good
Catalog No. TMAC-01933
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $216 | 7-10 days | |
| 100 μL | $318 | 7-10 days |
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Chemical Properties
| Description | Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM. |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1: 1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Immunogen affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. |
| Conjucates | Unconjugated |
| Others Formats | Methylated/Acetylated |
| Immunogen | Peptide |
| Antigen Species | Peptide |
| Uniprot ID |
| Molecular Weight | Theoretical: 17 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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