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Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

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Catalog No. TMAC-01933

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-01933
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1: 1000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationImmunogen affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Methylated/Acetylated
Antigen Details
Immunogen
Peptide
Antigen Species
Peptide
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 17 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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