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ATIC-IN-1 acetate

Name: ATIC-IN-1 acetate
Brand: TargetMol
SKU: T78159
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78159

ATIC-IN-1 acetate is an inhibitor of aminoimidazole-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) with potential anti-tumor activity. It inhibits AICAR Tfase by disrupting ATIC homo-dimerization.

ATIC-IN-1 acetate

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Purity: 99.89%

Catalog No. T78159

Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$142	In Stock
10 mg	$229	In Stock
25 mg	$478	In Stock
50 mg	$765	Backorder
1 mL x 10 mM (in DMSO)	$163	In Stock

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Batch Information

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Purity:99.89%

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COA HPLC MS

Product Introduction

Bioactivity

Description	ATIC-IN-1 acetate is an inhibitor of aminoimidazole-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) with potential anti-tumor activity. It inhibits AICAR Tfase by disrupting ATIC homo-dimerization.
Targets&IC50	aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC):685 nM （Ki）
In vitro	ATIC-IN-1 acetate (Compound 14) is an inhibitor of aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC) dimerization with a Ki value of 685 nM.[1] ATIC-IN-1 acetate (100-500 μM, treated for 48 hours) was able to hinder the proliferation of MCF-7 cells. [1] ATIC-IN-1 acetate (250 μM, 24-72 hours of action) decreases cell division rather than increasing cell death. [1]

Chemical Properties

Molecular Weight	523.59
Formula	C₂₃H₃₇N₇O₇
Smiles	O=[N+](C1=CC=C(C[C@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C(N(CC)CC)=O)C=C1)[O-].CC(O)=O

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40.00 mg/mL (76.40 mM), Sonication is recommended.

DMSO: 40.00 mg/mL (76.40 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9099 mL	9.5495 mL	19.0989 mL	95.4946 mL
5 mM	0.3820 mL	1.9099 mL	3.8198 mL	19.0989 mL
10 mM	0.1910 mL	0.9549 mL	1.9099 mL	9.5495 mL
20 mM	0.0955 mL	0.4775 mL	0.9549 mL	4.7747 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc