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N6-Cyclohexyladenosine

Name: N6-Cyclohexyladenosine
Brand: TargetMol
SKU: T12160
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12160Cas No. 36396-99-3

Alias CHA

N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm. N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor effects of lumbar sympathetic nerve stimulation in rats.

N6-Cyclohexyladenosine

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Purity: 99.98%

Catalog No. T12160Alias CHACas No. 36396-99-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	In Stock	In Stock
25 mg	$56	In Stock	In Stock
50 mg	$106	In Stock	In Stock
100 mg	$158	In Stock	In Stock
200 mg	$232	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA LCMS HNMR

Product Introduction

N6-Cyclohexyladenosine AI Summary

N6-Cyclohexyladenosine exhibits potent bioactivity as an adenosine receptor modulator with a high affinity for the adenosine A1 receptor, displaying Ki values as low as 1.3 nM. It shows selectivity towards the A1 receptor over the A2 receptor, with selectivity ratios up to 430, highlighting a significant preference for A1 receptor binding. The compound also demonstrates inhibitory effects on adenylyl cyclase in various tissues such as rat cortical membranes and adipocytes, with IC50 values ranging from 27.0 nM to as low as 1.4-1.6 nM in specific assays. Furthermore, N6-Cyclohexyladenosine is selective in its action, exhibiting lower affinity for the A2 receptor with Ki values around 363 to 750 nM. It has additional pharmacological implications, including potential antitumor activity, modulation of adenylate cyclase activity, and effects on heart rate and blood pressure in animal models. Broadly, N6-Cyclohexyladenosine may act as both an agonist and antagonist depending on the receptor subtype and exhibits various other bioactivities such as enhancing SMN2 splice variant expression and inhibiting Lassa virus entry into cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm. N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor effects of lumbar sympathetic nerve stimulation in rats.
Targets&IC50	A1:8.2 nm (EC50)
Synonyms	CHA

Chemical Properties

Molecular Weight	349.38
Formula	C₁₆H₂₃N₅O₄
Cas No.	36396-99-3
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCCC3)ncnc12
Relative Density.	1.71 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (283.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8622 mL	14.3111 mL	28.6221 mL	143.1107 mL
5 mM	0.5724 mL	2.8622 mL	5.7244 mL	28.6221 mL
10 mM	0.2862 mL	1.4311 mL	2.8622 mL	14.3111 mL
20 mM	0.1431 mL	0.7156 mL	1.4311 mL	7.1555 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8622 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4311 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc