NRG1 alpha Protein, Human, Recombinant (His)

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Catalog No. TMPY-02721

NRG1 alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5kDa and the accession number is Q02297-1.

NRG1 alpha Protein, Human, Recombinant (His)

Copy Product Info

Catalog No. TMPY-02721

NRG1 alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5kDa and the accession number is Q02297-1.

Pack Size	Price	USA Warehouse	Global Warehouse
5 μg	$55	7-10 days	7-10 days
10 μg	$87	7-10 days	7-10 days
20 μg	$142	7-10 days	7-10 days
50 μg	$277	7-10 days	7-10 days
100 μg	$535	7-10 days	7-10 days
200 μg	$815	7-10 days	7-10 days
500 μg	$1,680	7-10 days	7-10 days
1 mg	$3,480	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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Biological Activity	1. Measured by its ability to biotinylated Human ErbB4-Fc in functional Elisa. 2. Measured by its ability to biotinylated Rhesus ErbB3-His in functional Elisa. 3. Measured by its ability to biotinylated Rhesus ErbB3 in functional Elisa.
Description	NRG1 alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5kDa and the accession number is Q02297-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q02297-1
Synonyms	SMDF,NRG1-IT2,NRG1 α,neuregulin 1,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,GGF2,GGF,ARIA
Construction	A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) extracellular domain (Ser 20-Lys 241) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ser 20
Protein Purity	> 98 % as determined by SDS-PAGE
Molecular Weight	25.5kDa (predicted); 40-45 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.