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Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody
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Catalog No. TMAC-00564
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CARM1 (Ser228). Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody can be used in WB,IF.
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody
😃Good
Catalog No. TMAC-00564
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CARM1 (Ser228). Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody can be used in WB,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $216 | 7-10 days | |
| 100 μL | $316 | 7-10 days |
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| Description | Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CARM1 (Ser228). Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody can be used in WB,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 228(V-K-S(p)-N-N) derived from Human CARM1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 63 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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