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Mecillinam

Name: Mecillinam
Brand: TargetMol
SKU: T21369
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21369Cas No. 32887-01-7

Alias Penicillin HX, Mecillinamum, Hexacillin, Coactin, Amdinocillin

Mecillinam (Hexacillin), an extended-spectrum penicillin antibiotic, is considered to be active against Gram-negative bacteria by binding specifically to penicillin-binding protein 2 (PBP2). It is used primarily to treat urinary tract infections and has also been used in the treatment of paratyphoid fever and typhoid.

Mecillinam

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Purity: 95.53%

Catalog No. T21369Alias Penicillin HX, Mecillinamum, Hexacillin, Coactin, AmdinocillinCas No. 32887-01-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$35	In Stock	In Stock
25 mg	$53	In Stock	In Stock
50 mg	Preferential	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.53%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Mecillinam AI Summary

Mecillinam exhibits significant bioactivity against various aerobic organisms. It shows a minimum inhibitory concentration (MIC) of 12.5 µg/mL against Escherichia coli, Shigella species, and Salmonella schottmuelleri. Notably, it has MIC values of 8.0 µg/mL against Staphylococcus aureus strain 2865 and 0.125 µg/mL against Salmonella strain 3860. For Klebsiella pneumoniae strain 4005, the MIC is 16.0 µg/mL, whereas, for Enterobacter aerogenes strain 2828, it is higher at 64.0 µg/mL. The compound's effectiveness varies against other organisms such as Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, and Proteus mirabilis, with MIC values ranging from 0.5 µg/mL to over 128.0 µg/mL. Mecillinam shows limited to no inhibitory activity against Pseudomonas aeruginosa, Morganella morganii, and other tested strains, with MIC values exceeding 128.0 µg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mecillinam (Hexacillin), an extended-spectrum penicillin antibiotic, is considered to be active against Gram-negative bacteria by binding specifically to penicillin-binding protein 2 (PBP2). It is used primarily to treat urinary tract infections and has also been used in the treatment of paratyphoid fever and typhoid.
Synonyms	Penicillin HX, Mecillinamum, Hexacillin, Coactin, Amdinocillin

Chemical Properties

Molecular Weight	325.43
Formula	C₁₅H₂₃N₃O₃S
Cas No.	32887-01-7
Smiles	[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2\N=C\N1CCCCCC1)C(O)=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 250 mg/mL (768.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0729 mL	15.3643 mL	30.7286 mL	153.6429 mL
5 mM	0.6146 mL	3.0729 mL	6.1457 mL	30.7286 mL
10 mM	0.3073 mL	1.5364 mL	3.0729 mL	15.3643 mL
20 mM	0.1536 mL	0.7682 mL	1.5364 mL	7.6821 mL
50 mM	0.0615 mL	0.3073 mL	0.6146 mL	3.0729 mL
100 mM	0.0307 mL	0.1536 mL	0.3073 mL	1.5364 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc