Cytoskeletal Signaling Pathway Compound Library

Catalog No. L1310

Library Compound List Excel SDF

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including bacteria and archaea. It extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. In eukaryotes, it is composed of three main components, microfilaments, intermediate filaments and microtubules, and these are all capable of rapid growth or disassembly dependent on the cell's requirements. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microtubules provide structure and shape to eukaryotic cells and help localize membrane-enclosed organelles. Intermediate filaments have great tensile strength, and their main function is to enable cells to withstand the mechanical stress that occurs when cells are stretched.

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, establishment of the intracellular organization of the cytoplasm, establishment of cell polarity, and many other functions that are essential for cellular homeostasis and survival. Many diseases have now been associated with abnormalities in cytoskeletal and nucleoskeletal proteins, including neurodegeneration such as Alzheimer's Disease (AD) with the accumulation of amyloid beta peptide, and the intracellular neurofibrillary tangles that composed of paired helical filaments of the microtubule-associated protein, tau; cancer (invasion) with cytoskeleton aberration like reduced microtubule polymerization, etc.

TargetMol’s Cytoskeletal Signaling Pathway Compound Library collects 773 compounds related to cytoskeletal regulation with targets on Microtubule/Tubulin, Kinesin, PKC, MAPK, etc. It can be used for research in cytoskeletal signaling pathway, cytoskeleton associated disease, and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS；
Targets include Microtubule/Tubulin, Kinesin, PKC, MAPK, etc.;
Part of them are FDA-approved drugs;
Structural diversity with strong bioactivities and cell permeability;
Detailed compound information with structure, target, and biological activity description；
NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (145)

Microtubule Associated (114)

Autophagy (102)

p38 MAPK (96)

Akt (93)

Wnt/beta-catenin (92)

PKC (77)

Bcr-Abl (63)

HSP (57)

MAPK (50)

ROCK (40)

Integrin (36)

Src (36)

NF-κB (30)

FAK (29)

ERK (27)

PI3K (23)

PKA (22)

Parasite (21)

Antibacterial (20)

Kinesin (19)

VEGFR (19)

Endogenous Metabolite (19)

PAK (18)

c-Kit (18)

CDK (18)

mTOR (16)

PDGFR (16)

JNK (15)

Myosin (15)

PARP (13)

Antibiotic (13)

Rho (12)

Caspase (12)

Reactive Oxygen Species (12)

S6 Kinase (11)

TNF (11)

COX (11)

IGF-1R (10)

BCL (10)

FLT (9)

Aurora Kinase (9)

STAT (9)

FGFR (9)

Casein Kinase (8)

GSK-3 (8)

Antifungal (8)

AMPK (7)

Raf (7)

Dynamin (7)

EGFR (7)

Ras (6)

ALK (6)

JAK (6)

HIV Protease (6)

Gap Junction Protein (6)

ATPase (6)

MEK (6)

Influenza Virus (6)

Serine/threonin kinase (5)

ASK (5)

IL Receptor (5)

MMP (5)

PYK2 (5)

Tyrosine Kinases (5)

CaMK (5)

Topoisomerase (5)

c-Met/HGFR (5)

NO Synthase (5)

PPAR (5)

PDK (4)

SGK (4)

TLR (4)

Syk (4)

HER (4)

Lipoxygenase (4)

S1P Receptor (4)

p53 (4)

Ferroptosis (4)

Calcium Channel (4)

GPR (4)

DNA/RNA Synthesis (4)

Mitochondrial Metabolism (3)

Mitophagy (3)

Porcupine (3)

LDL (3)

SARS-CoV (3)

HSV (3)

Serine Protease (3)

HIF (3)

ACK (3)

c-RET (3)

Virus Protease (3)

Antifection (3)

Trk receptor (3)

P-gp (3)

c-Fms (3)

Gamma-secretase (3)

MyD88 (2)

Chk (2)

PLK (2)

Carbonic Anhydrase (2)

AChR (2)

BTK (2)

Nrf2 (2)

Monoamine Oxidase (2)

transporter (2)

Antiviral (2)

Antioxidant (2)

Adrenergic Receptor (2)

Beta Amyloid (2)

TGF-beta/Smad (2)

MNK (2)

PTEN (2)

RAAS (2)

HDAC (2)

HCV Protease (2)

Hck (2)

Guanylate cyclase (2)

KSP (2)

GRK (2)

LPL Receptor (2)

Prostaglandin Receptor (2)

Epigenetic Reader Domain (2)

Potassium Channel (2)

Ephrin Receptor (2)

Drug Metabolite (2)

DNA Alkylation (2)

MLK (2)

Tie-2 (1)

PROTACs (1)

TRP/TRPV Channel (1)

Phosphatase (1)

5-HT Receptor (1)

PERK (1)

Cannabinoid Receptor (1)

Estrogen Receptor/ERR (1)

DYRK (1)

DUB (1)

DNA (1)

DHFR (1)

CRISPR/Cas9 (1)

Complement System (1)

Aryl Hydrocarbon Receptor (1)

FXR (1)

Aromatase (1)

Arginase (1)

Apelin receptor (1)

Androgen Receptor (1)

Aminopeptidase (1)

AhR (1)

Adenosine Receptor (1)

Estrogen/progestogen Receptor (1)

Glucokinase (1)

PDE (1)

LRRK2 (1)

Nucleoside Antimetabolite/Analog (1)

NAMPT (1)

NADPH (1)

MRP (1)

Methionine Adenosyltransferase (MAT) (1)

MELK (1)

Mdm2 (1)

Ligands for Target Protein for PROTAC (1)

Glucosidase (1)

IκB/IKK (1)

IRAK (1)

Histamine Receptor (1)

HIF/HIF Prolyl-Hydroxylase (1)

Hedgehog/Smoothened (1)

HBV (1)

GST (1)

Glutathione Peroxidase (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty