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CRT-0105950

🥰Excellent
Catalog No. T23917Cas No. 1661845-86-8
Alias CRT0105950, CRT 0105950

CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.

CRT-0105950

CRT-0105950

🥰Excellent
Purity: 99.86%
Catalog No. T23917Alias CRT0105950, CRT 0105950Cas No. 1661845-86-8
CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$59In StockIn Stock
5 mg$143In StockIn Stock
10 mg$228In StockIn Stock
25 mg$463In StockIn Stock
50 mg$745In StockIn Stock
100 mg$1,190In StockIn Stock
1 mL x 10 mM (in DMSO)$158In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.86%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.
Targets&IC50
LIMK2:1 nM, LIMK1:0.3 nM
SynonymsCRT0105950, CRT 0105950
Chemical Properties
Molecular Weight393.89
FormulaC21H16ClN3OS
Cas No.1661845-86-8
SmilesCc1ccc(c(Cl)c1)-c1cnccc1-c1cnc(Nc2ccc(O)cc2)s1
Relative Density.1.364 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (253.88 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.16 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5388 mL12.6939 mL25.3878 mL126.9390 mL
5 mM0.5078 mL2.5388 mL5.0776 mL25.3878 mL
10 mM0.2539 mL1.2694 mL2.5388 mL12.6939 mL
20 mM0.1269 mL0.6347 mL1.2694 mL6.3469 mL
50 mM0.0508 mL0.2539 mL0.5078 mL2.5388 mL
100 mM0.0254 mL0.1269 mL0.2539 mL1.2694 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TubulinMicrotubuleAssociatedMicrotubule AssociatedLIMKinaseLIMK2LIMK1LIM KinaseCRT-0105950
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