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SYR127063

Name: SYR127063
Brand: TargetMol
SKU: T34760
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T34760Cas No. 871026-18-5

Alias SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454

SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.

SYR127063

🥰Excellent

Purity: 98.57%

Catalog No. T34760Alias SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454Cas No. 871026-18-5

SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.

Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$302	In Stock
10 mg	$453	In Stock
25 mg	$747	In Stock
50 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$373	In Stock

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Batch Information

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Purity:98.57%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
Targets&IC50	EGFR:429 nM, HER4: > 10000 nM, HER2:11 nM
In vitro	IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM
Synonyms	SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454

Chemical Properties

Molecular Weight	492.88
Formula	C₂₃H₂₀ClF₃N₄O₃
Cas No.	871026-18-5
Smiles	OCCOCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (111.59 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0289 mL	10.1445 mL	20.2889 mL	101.4446 mL
5 mM	0.4058 mL	2.0289 mL	4.0578 mL	20.2889 mL
10 mM	0.2029 mL	1.0144 mL	2.0289 mL	10.1445 mL
20 mM	0.1014 mL	0.5072 mL	1.0144 mL	5.0722 mL
50 mM	0.0406 mL	0.2029 mL	0.4058 mL	2.0289 mL
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc