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SYR127063

Name: SYR127063
Brand: TargetMol
SKU: T34760
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34760Cas No. 871026-18-5

Alias SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454

SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.

SYR127063

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Purity: 98.57%

Catalog No. T34760Alias SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454Cas No. 871026-18-5

SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	In Stock	In Stock
5 mg	$302	In Stock	In Stock
10 mg	$453	In Stock	In Stock
25 mg	$747	In Stock	In Stock
50 mg	$1,050	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$373	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
Targets&IC50	EGFR:429 nM, HER4: > 10000 nM, HER2:11 nM
In vitro	IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM
Synonyms	SYR-127063, SYR 127063, BDBM-92454, BDBM92454, BDBM 92454

Chemical Properties

Molecular Weight	492.88
Formula	C₂₃H₂₀ClF₃N₄O₃
Cas No.	871026-18-5
Smiles	OCCOCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (111.59 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0289 mL	10.1445 mL	20.2889 mL	101.4446 mL
5 mM	0.4058 mL	2.0289 mL	4.0578 mL	20.2889 mL
10 mM	0.2029 mL	1.0144 mL	2.0289 mL	10.1445 mL
20 mM	0.1014 mL	0.5072 mL	1.0144 mL	5.0722 mL
50 mM	0.0406 mL	0.2029 mL	0.4058 mL	2.0289 mL
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc