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Urolithin A

Name: Urolithin A
Brand: TargetMol
SKU: T7174
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7174Cas No. 1143-70-0

Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.

Urolithin A

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Purity: 99.67%

Catalog No. T7174Cas No. 1143-70-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$66	In Stock	In Stock
25 mg	$132	In Stock	In Stock
50 mg	$197	In Stock	In Stock
100 mg	$337	In Stock	In Stock
200 mg	$497	-	In Stock
500 mg	$793	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
Targets&IC50	Caco-2 cells:49 μM, St-T1b cells:39.88 µM, T24 cells:43.9 μM, SW620 cells:53.561 μM, 12Z endometriotic cells:40.46 µM, CK2:0.39 𝜇M
In vitro	METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1] METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2]
In vivo	METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models. RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3]

Chemical Properties

Molecular Weight	228.2
Formula	C₁₃H₈O₄
Cas No.	1143-70-0
Smiles	Oc1ccc2c(c1)oc(=O)c1cc(O)ccc21
Relative Density.	1.516 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (1062.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.91 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3821 mL	21.9106 mL	43.8212 mL	219.1060 mL
5 mM	0.8764 mL	4.3821 mL	8.7642 mL	43.8212 mL
10 mM	0.4382 mL	2.1911 mL	4.3821 mL	21.9106 mL
20 mM	0.2191 mL	1.0955 mL	2.1911 mL	10.9553 mL
50 mM	0.0876 mL	0.4382 mL	0.8764 mL	4.3821 mL
100 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1911 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc