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Ascaridole

Name: Ascaridole
Brand: TargetMol
SKU: T25114
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25114Cas No. 512-85-6

Alias NSC-406266, NSC406266, NSC 406266

Ascaridole (NSC-406266) acts as an anthelmintic compound that repels parasitic helminths (worms) in humans and plants and has weak antimalarial activity.

Ascaridole

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Purity: 99.93%

Catalog No. T25114Alias NSC-406266, NSC406266, NSC 406266Cas No. 512-85-6

Ascaridole (NSC-406266) acts as an anthelmintic compound that repels parasitic helminths (worms) in humans and plants and has weak antimalarial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$72	In Stock	In Stock
500 mg	$222	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Liquid

Resource Download

COA LCMS HNMR

Product Introduction

Ascaridole AI Summary

Ascaridole exhibits a range of biological activities across different experimental models. It demonstrates moderate cytotoxicity against mouse EAC cells with an IC80 value greater than 500.0 µM and an IC50 value greater than 500,000.0 nM, achieving 74.8% activity at concentrations above 500 µM. In antiparasitic studies, the compound shows trypanocidal activity with a minimal lethal concentration of 23.0 µM against Trypanosoma cruzi Tulahuen epimastigotes within 24 hours. It effectively reduces Trypanosoma cruzi trypomastigote infection rates in HeLa cells to 8.5% and decreases amastigote counts to 22.8% at a concentration of 1 µg/mL over 4 days. Furthermore, Ascaridole exhibits significant nematocidal activity with LC50 values of 365.0 µg/mL for Aphelenchoides besseyi and 52.0 µg/mL for Meloidogyne incognita after 24 hours. It induces less than 50.0% mortality in Aphelenchoides besseyi at 200 µg/mL while causing complete mortality in Meloidogyne incognita at 100 µg/mL. Additionally, the compound has sedative properties in ddY mice, reducing spontaneous locomotor activity and enhancing pentobarbital-induced sleep, with decreased caffeine-induced locomotor activity post-stimulation. The LD50 toxicity value in mice is established at 400.0 mg/kg..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ascaridole (NSC-406266) acts as an anthelmintic compound that repels parasitic helminths (worms) in humans and plants and has weak antimalarial activity.
Synonyms	NSC-406266, NSC406266, NSC 406266

Chemical Properties

Molecular Weight	168.23
Formula	C₁₀H₁₆O₂
Cas No.	512-85-6
Smiles	C(C)(C)C12CCC(C)(C=C1)OO2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1456.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9442 mL	29.7212 mL	59.4424 mL	297.2122 mL
5 mM	1.1888 mL	5.9442 mL	11.8885 mL	59.4424 mL
10 mM	0.5944 mL	2.9721 mL	5.9442 mL	29.7212 mL
20 mM	0.2972 mL	1.4861 mL	2.9721 mL	14.8606 mL
50 mM	0.1189 mL	0.5944 mL	1.1888 mL	5.9442 mL
100 mM	0.0594 mL	0.2972 mL	0.5944 mL	2.9721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc