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Vinpocetine
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Catalog No. T0167Cas No. 42971-09-5
Alias RGH-4405, Ethyl apovincaminate
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Vinpocetine
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Purity: 99.98%
Catalog No. T0167Alias RGH-4405, Ethyl apovincaminateCas No. 42971-09-5
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $35 | In Stock | In Stock | |
| 500 mg | $98 | In Stock | In Stock | |
| 1 g | $118 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Vinpocetine AI Summary
Vinpocetine demonstrates a wide array of bioactivities across various biological systems. It exhibits inhibitory activity against Phosphodiesterase 1 (PDE1) with an IC50 value of 19000 nM from bovine aorta and 30000 nM from unknown origin, and a Ki value of 14000 nM for human PDE1. The compound also shows weak inhibition of PDE3 and PDE5 with IC50 values greater than 300000 nM. It has been evaluated for acid sphingomyelinase inhibition in human H4 cells, lipid peroxidation in rat brains, memory modulation in rodents, and antiplasmodial activity with IC50 values ranging from 7943.28 nM to 12589.25 nM against Plasmodium falciparum. Vinpocetine also displays vasorelaxant effects in rat thoracic aortic rings and inhibitory activities on various enzymes like ALDH1A1, ERG, and HDAC6. Notably, it exhibits antiviral activity against SARS-CoV-2 in VERO-6 cells and inhibitory effects on the SARS-CoV-2 3CL-Pro protease.
Furthermore, Vinpocetine shows binding affinity to PDE1A and influences vertebral and femoral blood flow in dogs, with a potency ratio of 1.0 compared to vinpocetine. It inhibits transport activity of OATP1B1/1B3 transfected CHO cells and demonstrates mixed effects on the viability of various cell lines, including HEK293T, U2OS, and human fibroblasts. The compound demonstrates a log P value of 0.94 for its cationic form and 4.45 for its noncharged form, with a log D value of 0.94, indicating its distribution characteristics. Additionally, it shows stability in mouse plasma with a half-life of 13.1 hours. Overall, the diverse bioactivities of Vinpocetine suggest its potential for various pharmacological applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). |
| Targets&IC50 | PDE1:21 μM, IKK:17.17 μM |
| Synonyms | RGH-4405, Ethyl apovincaminate |
| Molecular Weight | 350.45 |
| Formula | C22H26N2O2 |
| Cas No. | 42971-09-5 |
| Smiles | CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)N1C1=C4C=CC=C1 |
| Relative Density. | 1.28 g/cm3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: 17.5 mg/mL (49.94 mM), Sonication is recommended. DMSO: 8.68 mg/mL (24.77 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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