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JTK-109
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Catalog No. T27696Cas No. 480462-62-2
Alias JTK109
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
JTK-109
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Purity: 99.68%
Catalog No. T27696Alias JTK109Cas No. 480462-62-2
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $329 | In Stock | In Stock | |
| 5 mg | $798 | In Stock | In Stock | |
| 10 mg | $1,090 | In Stock | In Stock | |
| 25 mg | $1,650 | In Stock | In Stock | |
| 50 mg | $2,230 | In Stock | In Stock | |
| 100 mg | $2,930 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $1,230 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.68%
Appearance:Solid
Color:White
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Product Introduction
JTK-109 AI Summary
JTK-109 exhibits potent bioactivity against Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerases, with IC50 values ranging from 12.0 nM to 6400.0 nM against varying genotypes, including an IC50 of 170.0 nM for HCV genotype 1b. It particularly inhibits the HCV 1b NS5B RNA polymerase P495L mutant with an IC50 of 1500.0 nM. Furthermore, JTK-109 shows moderate inhibition of HCV subgenomic RNA replication in Huh5-2 cells, with an EC50 of 320.0 nM, and a therapeutic index ratio (CC50/EC50) of 78.0, indicating a favorable safety profile. The compound has low cytotoxicity against Huh-5-2 cells with a CC50 greater than 20000.0 nM and shows high oral bioavailability in rats at 10 mg/kg, with a bioavailability percentage of 36.0% and a liver concentration of 78.5 µM. It achieves plasma concentrations of 4.0 µM to 4.5 µM in rats after administration of 30 mg/kg within 1 to 2 hours and has a half-life of 2.1 hours at 10 mg/kg. JTK-109 exhibits no significant activity against DNA polymerases, HIV reverse transcriptase, or mammalian DNA-dependent RNA polymerases, with IC50 values above 10,000.0 nM in these assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes. |
| Synonyms | JTK109 |
| Molecular Weight | 638.13 |
| Formula | C37H33ClFN3O4 |
| Cas No. | 480462-62-2 |
| Smiles | FC1=C(C=2N(C=3C(N2)=CC(C(O)=O)=CC3)C4CCCCC4)C=CC(OCC5=C(C=CC(=C5)N6C(=O)CCC6)C7=CC=C(Cl)C=C7)=C1 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.39 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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