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JTK-109

Name: JTK-109
Brand: TargetMol
SKU: T27696
Price: 329 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: JTK109) Copy Product Info

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Synonyms: JTK109

Catalog No. T27696 Copy Product Info

Purity: 99.68%

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JTK-109 is a hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor with an IC₅₀ value of 0.017 μM. JTK-109 inhibits the G1b and G3a subgenomic replicases and the recombinase by targeting the Thumb-1 (T1) allosteric site of the NS5B polymerase. JTK-109 can be used in research on hepatitis C virus and cupovirus.

Cas No. 480462-62-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$329	In Stock	In Stock
5 mg	$798	In Stock	In Stock
10 mg	$1,090	In Stock	In Stock
25 mg	$1,650	In Stock	In Stock
50 mg	$2,230	In Stock	In Stock
100 mg	$2,930	-	In Stock
1 mL x 10 mM (in DMSO)	$1,230	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.68%

Appearance:Solid

Color:White

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COA FNMR HNMR LCMS

Product Introduction

JTK-109 AI Summary

JTK-109 exhibits potent bioactivity against Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerases, with IC50 values ranging from 12.0 nM to 6400.0 nM against varying genotypes, including an IC50 of 170.0 nM for HCV genotype 1b. It particularly inhibits the HCV 1b NS5B RNA polymerase P495L mutant with an IC50 of 1500.0 nM. Furthermore, JTK-109 shows moderate inhibition of HCV subgenomic RNA replication in Huh5-2 cells, with an EC50 of 320.0 nM, and a therapeutic index ratio (CC50/EC50) of 78.0, indicating a favorable safety profile. The compound has low cytotoxicity against Huh-5-2 cells with a CC50 greater than 20000.0 nM and shows high oral bioavailability in rats at 10 mg/kg, with a bioavailability percentage of 36.0% and a liver concentration of 78.5 µM. It achieves plasma concentrations of 4.0 µM to 4.5 µM in rats after administration of 30 mg/kg within 1 to 2 hours and has a half-life of 2.1 hours at 10 mg/kg. JTK-109 exhibits no significant activity against DNA polymerases, HIV reverse transcriptase, or mammalian DNA-dependent RNA polymerases, with IC50 values above 10,000.0 nM in these assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JTK-109 is a hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor with an IC₅₀ value of 0.017 μM. JTK-109 inhibits the G1b and G3a subgenomic replicases and the recombinase by targeting the Thumb-1 (T1) allosteric site of the NS5B polymerase. JTK-109 can be used in research on hepatitis C virus and cupovirus.
In vitro	Methods: Huh-7 cells stably expressing G1b, G2a, and G3a subgenomic replicons were treated with JTK-109 at concentrations ranging from 0.01 nM to 100 μM for 72 hours, followed by luciferase activity assay. Results: JTK-109 exhibited efficacy against G1b and G3a, but its activity against G2a was reduced by 41-fold. [1]
Synonyms	JTK109

Chemical Properties

Molecular Weight	638.13
Formula	C₃₇H₃₃ClFN₃O₄
Cas No.	480462-62-2
Smiles	FC1=C(C=2N(C=3C(N2)=CC(C(O)=O)=CC3)C4CCCCC4)C=CC(OCC5=C(C=CC(=C5)N6C(=O)CCC6)C7=CC=C(Cl)C=C7)=C1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.39 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5671 mL	7.8354 mL	15.6708 mL	78.3539 mL
5 mM	0.3134 mL	1.5671 mL	3.1342 mL	15.6708 mL
10 mM	0.1567 mL	0.7835 mL	1.5671 mL	7.8354 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.