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ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-05435
Synonyms: angiopoietin 1, AGPT, AGP1, ANG1

ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is Q15389-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 373.00
200 μg 5 days $ 633.00
500 μg 5 days $ 1,980.00
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Biological Description
Technical Params
Product Properties
Biological Information Testing in progress
Description ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is Q15389-1.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q15389-1
Synonyms angiopoietin 1, AGPT, AGP1, ANG1
Construction The Human ANGPT1 ( NP_001137.2) (Met1-Leu261 and Arg277-Phe498 linked by a polypeptide linker) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 85 % as determined by SDS-PAGE.

Molecular Weight 82 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.

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Keywords

ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) angiopoietin 1 ANG 1 AGP 1 AGPT ANG-1 AGP-1 AGP1 ANG1 recombinant recombinant-proteins proteins protein

 

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