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BDP-13176

Name: BDP-13176
Brand: TargetMol
SKU: T9075
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9075Cas No. 2290660-61-4

BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent

BDP-13176

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Purity: 99.26%

Catalog No. T9075Cas No. 2290660-61-4

BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$217	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$490	In Stock	In Stock
50 mg	$675	In Stock	In Stock
100 mg	$942	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent
Targets&IC50	Fascin 1:240 nM, Fascin 1:90 nM(Kd)
In vitro	BDP-13176 (0-1 μM) inhibits fascin 1 bundling activity. Fascin, an actin-binding and bundling protein, is not present in normal epithelial tissues but is overexpressed in various invasive epithelial tumors. It plays a crucial role in cancer cell metastasis by enhancing cell migration and invasion.

Chemical Properties

Molecular Weight	497.38
Formula	C₂₄H₂₂Cl₂N₆O₂
Cas No.	2290660-61-4
Smiles	Clc1ccc(Cn2cc(C(=O)Nc3ccncc3)c3n(ncc3c2=O)C2CCNCC2)cc1Cl
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (251.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0527 mL	20.1054 mL	100.5268 mL
5 mM	0.4021 mL	2.0105 mL	4.0211 mL	20.1054 mL
10 mM	0.2011 mL	1.0053 mL	2.0105 mL	10.0527 mL
20 mM	0.1005 mL	0.5026 mL	1.0053 mL	5.0263 mL
50 mM	0.0402 mL	0.2011 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2011 mL	1.0053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc