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BDP-13176

Name: BDP-13176
Brand: TargetMol
SKU: T9075
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9075Cas No. 2290660-61-4

BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent

BDP-13176

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Purity: 99.26%

Catalog No. T9075Cas No. 2290660-61-4

BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$217	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$490	In Stock	In Stock
50 mg	$675	In Stock	In Stock
100 mg	$942	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.26%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent
Targets&IC50	Fascin 1:240 nM, Fascin 1:90 nM(Kd)
In vitro	BDP-13176 (0-1 μM) inhibits fascin 1 bundling activity. Fascin, an actin-binding and bundling protein, is not present in normal epithelial tissues but is overexpressed in various invasive epithelial tumors. It plays a crucial role in cancer cell metastasis by enhancing cell migration and invasion.

Chemical Properties

Molecular Weight	497.38
Formula	C₂₄H₂₂Cl₂N₆O₂
Cas No.	2290660-61-4
Smiles	Clc1ccc(Cn2cc(C(=O)Nc3ccncc3)c3n(ncc3c2=O)C2CCNCC2)cc1Cl
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (251.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0527 mL	20.1054 mL	100.5268 mL
5 mM	0.4021 mL	2.0105 mL	4.0211 mL	20.1054 mL
10 mM	0.2011 mL	1.0053 mL	2.0105 mL	10.0527 mL
20 mM	0.1005 mL	0.5026 mL	1.0053 mL	5.0263 mL
50 mM	0.0402 mL	0.2011 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2011 mL	1.0053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc