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IMB-301

🥰Excellent
Catalog No. T9212Cas No. 64009-84-3

IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.

IMB-301

IMB-301

🥰Excellent
Purity: 99.72%
Catalog No. T9212Cas No. 64009-84-3
IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$41In StockIn Stock
5 mg$98In StockIn Stock
10 mg$158In StockIn Stock
25 mg$273In StockIn Stock
50 mg$389In StockIn Stock
100 mg$557In StockIn Stock
200 mg$758-In Stock
1 mL x 10 mM (in DMSO)$107In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.72%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.
In vitro
IMB-301 binds to hA3G that interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G.
Chemical Properties
Molecular Weight379.26
FormulaC19H17Cl2FN2O
Cas No.64009-84-3
SmilesFc1ccc(OCCC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
Relative Density.1.27 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (237.3 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6367 mL13.1836 mL26.3671 mL131.8357 mL
5 mM0.5273 mL2.6367 mL5.2734 mL26.3671 mL
10 mM0.2637 mL1.3184 mL2.6367 mL13.1836 mL
20 mM0.1318 mL0.6592 mL1.3184 mL6.5918 mL
50 mM0.0527 mL0.2637 mL0.5273 mL2.6367 mL
100 mM0.0264 mL0.1318 mL0.2637 mL1.3184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

replicationInhibitorinhibitIMB-301IMB301IMB 301Human immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVhA3G-VifhA3GAPOBEC3G
Related Tags: buy IMB-301 | purchase IMB-301 | IMB-301 cost | order IMB-301 | IMB-301 chemical structure | IMB-301 in vitro | IMB-301 formula | IMB-301 molecular weight
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