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TCN 201
🥰Excellent
Catalog No. T7870Cas No. 852918-02-6
Alias TCN-201
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
TCN 201
🥰Excellent
Purity: 98.5%
Catalog No. T7870Alias TCN-201Cas No. 852918-02-6
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $59 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $182 | In Stock | |
| 50 mg | $318 | In Stock | |
| 100 mg | $593 | In Stock |
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Purity:98.5%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit. |
| In vitro | TCN-201, a new GluN1/GluN2A-selective NMDA receptor antagonist whose inhibition can be surmounted by glycine.?Electrophysiological recordings from chimeric and mutant rat NMDA receptors suggest that TCN-201 binds to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 agonist binding domains.?Occupancy of this site by TCN-201 inhibits NMDA receptor function by reducing glycine potency.?TCN-201 is therefore a negative allosteric modulator of glycine binding[1]. |
| Synonyms | TCN-201 |
| Molecular Weight | 461.89 |
| Formula | C21H17ClFN3O4S |
| Cas No. | 852918-02-6 |
| Smiles | Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (43.3 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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