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Racecadotril

Name: Racecadotril
Brand: TargetMol
SKU: T1176
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1176Cas No. 81110-73-8

Alias Acetorphan

Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

Racecadotril

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Purity: 99.66%

Catalog No. T1176Alias AcetorphanCas No. 81110-73-8

Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$37	In Stock	In Stock
200 mg	$48	In Stock	In Stock
500 mg	$72	In Stock	In Stock
1 g	$90	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.66%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Racecadotril AI Summary

Racecadotril exhibits a broad spectrum of bioactivities and pharmacological properties. Primarily, it demonstrates resistance in drug-resistant human KBV1 and KB-3-1 cells with IC50 values of 1.27 μM and 2.93 μM, respectively. It acts as an inhibitor of Plasmodium falciparum proliferation, displaying potency ranging from 7.5 nM to 23.694.5 nM against different strains of the parasite. Moreover, Racecadotril inhibits human BSEP with an IC50 of 20.3 μM and human MRP2, MRP3, and MRP4 with IC50 values greater than 133 μM, 99 μM, and greater than 133 μM, respectively. The compound shows low activity against SARS-CoV-2 with an inhibition index of 0.3032 in Vero E6 cells and weak antiviral activity (IC50 > 20 μM) in HRCE cells. Racecadotril also displays moderate antifungal activity against Candida albicans and Cryptococcus neoformans, and antibacterial activity against several bacteria, including Escherichia coli and Staphylococcus aureus MRSA. It exhibits weak inhibition of human HDAC6 in an enzymatic assay, showing varying inhibitory percentages depending on the substrate used. Additionally, it acts as an antagonist for several nuclear receptors and shows binding affinity and inhibition for multiple receptors and transporters such as KCNH2, ADRB1, and Ptgs1. Overall, Racecadotril is a multifunctional compound with a wide range of bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Targets&IC50	Enkephalinase:4.5 μM
Synonyms	Acetorphan

Chemical Properties

Molecular Weight	385.48
Formula	C₂₁H₂₃NO₄S
Cas No.	81110-73-8
Smiles	C(CC1=CC=CC=C1)(C(NCC(OCC2=CC=CC=C2)=O)=O)CSC(C)=O
Relative Density.	1.206

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (116.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 71 mg/mL (184.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5942 mL	12.9708 mL	25.9417 mL	129.7084 mL
5 mM	0.5188 mL	2.5942 mL	5.1883 mL	25.9417 mL
10 mM	0.2594 mL	1.2971 mL	2.5942 mL	12.9708 mL
20 mM	0.1297 mL	0.6485 mL	1.2971 mL	6.4854 mL
50 mM	0.0519 mL	0.2594 mL	0.5188 mL	2.5942 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	1.2971 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc