IL-11 Protein, Human, Recombinant (His)

Name: IL-11 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPK-00088
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Oprelvekin, Interleukin-11, interleukin 11, INN: Oprelvekin, IL-11Oprelvekin, IL11, AGIF, Adipogenesis inhibitory factor) Copy Product Info

Synonyms: Oprelvekin, Interleukin-11, interleukin 11, INN: Oprelvekin, IL-11Oprelvekin, IL11, AGIF, Adipogenesis inhibitory factor

Catalog No. TMPK-00088 Copy Product Info

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions. IL-11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 20.24 kDa and the accession number is P20809-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$37	-	In Stock
10 µg	$56	-	In Stock
20 µg	$88	-	In Stock
50 µg	$168	7-10 days	7-10 days
100 µg	$278	-	In Stock
200 µg	$493	7-10 days	7-10 days
500 µg	$1,120	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Immobilized Human IL-11, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-11 R alpha, hFc Tag with the EC50 of 26.2ng/ml determined by ELISA (QC Test). 2.Human IL-11R alpha, His Tag immobilized on CM5 Chip can bind Human IL-11, His Tag with an affinity constant of 1.86 nM as determined in SPR assay.
Description	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions. IL-11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 20.24 kDa and the accession number is P20809-1.
Species	Human
Expression System	HEK293 Cells
Tag	N-His
Accession Number	P20809-1
Construction	Pro22-Leu199
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Oprelvekin, Interleukin-11, interleukin 11, INN: Oprelvekin, IL-11Oprelvekin, IL11, AGIF, Adipogenesis inhibitory factor
Research Background	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.

Chemical Properties

Molecular Weight

20.24 kDa (predicted). Due to glycosylation, the protein migrates to 21-25 kDa based on Tris-Bis PAGE result.

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.