Shopping Cart
Remove All
Your shopping cart is currently empty
SSD114 HCl
Copy Product Info
😃Good
Catalog No. T4522Cas No. 2319790-02-6
SSD114 is a novel GABAB receptor positive allosteric modulator.
SSD114 HCl
Copy Product Info😃Good
Purity: 99.95%
Catalog No. T4522Cas No. 2319790-02-6
SSD114 is a novel GABAB receptor positive allosteric modulator.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $119 | In Stock | In Stock | |
| 50 mg | $190 | In Stock | In Stock | |
| 100 mg | $323 | In Stock | In Stock | |
| 200 mg | $466 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $41 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.95%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SSD114 is a novel GABAB receptor positive allosteric modulator. |
| In vitro | In conditions containing 10 μM GABA, 25 μM SSD114 hydrochloride significantly increased the level of [35S]GTPγS activation induced by GABA alone to approximately 170% of basal levels.SSD114 hydrochloride (15 or 30 μM) caused a shift in the GABA concentration-response curve to the left and at the highest concentration slightly increased the maximal stimulatory effect of GABA. In the co-presence of 15 and 30 μM SSD114 hydrochloride, the EC50 of GABA was reduced by 2-fold and 2.5-fold, respectively, while the maximal stimulatory effect (Emax) was enhanced only at the 30 μM concentration to 161 ± 5.09% of the basal value [1]. |
| In vivo | SSD114 hydrochloride pretreatment significantly shortened the onset time of the loss-of-orientation reflex (LORR) [F(5,30)=4.55, P<0.005]. Follow-up analyses showed that the onset time of LORR was significantly shorter in the group of mice that received pretreatment at doses equal to or higher than 10 mg/kg SSD114 hydrochloride compared to the control group. In addition, SSD114 hydrochloride pretreatment prolonged the duration of LORR [F(5,30)=4.81, P<0.005]. Follow-up analysis indicated that the LORR duration was significantly prolonged in the group of mice receiving 10 and 100 mg/kg SSD114 hydrochloride pretreatment compared to the control group [1]. |
| Molecular Weight | 387.83 |
| Formula | C18H21ClF3N3O |
| Cas No. | 2319790-02-6 |
| Smiles | Cl.COc1cc(nc(NC2CCCCC2)n1)-c1ccc(cc1)C(F)(F)F |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (116.03 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.45 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy SSD114 HCl | purchase SSD114 HCl | SSD114 HCl cost | order SSD114 HCl | SSD114 HCl chemical structure | SSD114 HCl in vivo | SSD114 HCl in vitro | SSD114 HCl formula | SSD114 HCl molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.