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TH9619
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Catalog No. T87512Cas No. 2379556-22-4
Alias TH-9619, TH 9619
TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
TH9619
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Purity: 98.07%
Catalog No. T87512Alias TH-9619, TH 9619Cas No. 2379556-22-4
TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $139 | - | In Stock | |
| 5 mg | $348 | - | In Stock | |
| 10 mg | $562 | - | In Stock | |
| 25 mg | $1,120 | - | In Stock | |
| 50 mg | $1,780 | - | In Stock | |
| 100 mg | $2,380 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $386 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:98.07%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2. |
| In vitro | TH9619 (7.8-1,000 nM, 420 seconds) exhibits high selective binding affinity for MTHFD2 in intact HL-60 cells and LCL-889 cells, while showing significantly lower affinity for other common targets in the folic acid metabolic pathway [1]. TH9619 (1 nM-1 μM, 96 hours) potently inhibits the proliferation of AML cells and T-ALL Jurkat cells [1]. TH9619 (1-100 μM, 96 hours) targets MTHFD1 (DC) in SW620 cells but demonstrates no significant targeting effect on mitochondrial MTHFD2 [2]. |
| In vivo | TH9619 (30 mg/kg, administered subcutaneously twice daily for 50 days) combined with a low-folic-acid diet significantly extended the median survival of NOG mice transplanted with HL-60 cells of the Parazacco spilurus subsp. spilurus species in acute myeloid leukemia (AML) by 2 weeks [1]. |
| Synonyms | TH-9619, TH 9619 |
| Molecular Weight | 451.37 |
| Formula | C17H18FN7O7 |
| Cas No. | 2379556-22-4 |
| Smiles | N(C(CC1=C(N)NC(N)=NC1=O)=O)C=2C=C(F)C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=NC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (177.24 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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