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TH9619
🥰Excellent
Catalog No. T87512Cas No. 2379556-22-4
Alias TH-9619, TH 9619
TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
TH9619
🥰Excellent
Purity: 98.07%
Catalog No. T87512Alias TH-9619, TH 9619Cas No. 2379556-22-4
TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $139 | - | In Stock | |
| 5 mg | $348 | - | In Stock | |
| 10 mg | $562 | - | In Stock | |
| 25 mg | $1,120 | - | In Stock | |
| 50 mg | $1,780 | - | In Stock | |
| 100 mg | $2,380 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $386 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.07%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2. |
| In vitro | TH9619 (7.8-1,000 nM, 420 seconds) exhibits high selective binding affinity for MTHFD2 in intact HL-60 cells and LCL-889 cells, while showing significantly lower affinity for other common targets in the folic acid metabolic pathway [1]. TH9619 (1 nM-1 μM, 96 hours) potently inhibits the proliferation of AML cells and T-ALL Jurkat cells [1]. TH9619 (1-100 μM, 96 hours) targets MTHFD1 (DC) in SW620 cells but demonstrates no significant targeting effect on mitochondrial MTHFD2 [2]. |
| In vivo | TH9619 (30 mg/kg, administered subcutaneously twice daily for 50 days) combined with a low-folic-acid diet significantly extended the median survival of NOG mice transplanted with HL-60 cells of the Parazacco spilurus subsp. spilurus species in acute myeloid leukemia (AML) by 2 weeks [1]. |
| Synonyms | TH-9619, TH 9619 |
| Molecular Weight | 451.37 |
| Formula | C17H18FN7O7 |
| Cas No. | 2379556-22-4 |
| Smiles | N(C(CC1=C(N)NC(N)=NC1=O)=O)C=2C=C(F)C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=NC2 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (177.24 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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