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AMI-193

Catalog No. T21855 CAS 510-74-7

Synonyms: Espiramida, Spiramide

AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.

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AMI-193, CAS 510-74-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.04%

Biological Description

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Description	AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.
In vivo	In adult male squirrel monkeys, AMI-193 (0.003 and 0.01 mg/kg; i.m.) decreases the response rate under a fixed-interval (FI) schedule of stimulus termination in a dose-dependent manner and under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). AMI-193 (0.003 and 0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine[2].

Synonyms	Espiramida, Spiramide
Molecular Weight	383.46
Formula	C22H26FN3O2
CAS No.	510-74-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (39.12 mM), Sonication is recommended.

References and Literature

1. Kjellberg B, et, al. Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine. Arch Int Pharmacodyn Ther. 1974 Jul;210(1):61-6. 2. Ismaiel AM, et, al. Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem. 1993 Aug 20;36(17):2519-25. 3. Czoty PW, et, al. Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct;67(2):257-64.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library

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Keywords

AMI-193 510-74-7 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Espiramida AMI 193 Spiramide AMI193 inhibitor inhibit

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