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AMI-193

Name: AMI-193
Brand: TargetMol
SKU: T21855
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21855Cas No. 510-74-7

Alias Spiramide, Espiramida

AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.

AMI-193

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Purity: 99.65%

Catalog No. T21855Alias Spiramide, EspiramidaCas No. 510-74-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$136	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$333	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.
Targets&IC50	D2 Receptor:3 nM (Ki), 5-HT1A receptor:50 nM (Ki), 5-HT2 receptor:2 nM (Ki), 5-HT1C receptor:4300 nM (Ki), D1 receptor:2530 nM (Ki)
In vivo	In adult male squirrel monkeys, AMI-193 (0.003 and 0.01 mg/kg; i.m.) decreases the response rate under a fixed-interval (FI) schedule of stimulus termination in a dose-dependent manner and under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). AMI-193 (0.003 and 0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine[2].
Synonyms	Spiramide, Espiramida

Chemical Properties

Molecular Weight	383.46
Formula	C₂₂H₂₆FN₃O₂
Cas No.	510-74-7
Smiles	FC1=CC=C(OCCCN2CCC3(CC2)N(CNC3=O)C2=CC=CC=C2)C=C1
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.7 mg/mL (53.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6078 mL	13.0392 mL	26.0783 mL	130.3917 mL
5 mM	0.5216 mL	2.6078 mL	5.2157 mL	26.0783 mL
10 mM	0.2608 mL	1.3039 mL	2.6078 mL	13.0392 mL
20 mM	0.1304 mL	0.6520 mL	1.3039 mL	6.5196 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6078 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc