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Gelsevirine

🥰Excellent
Catalog No. TN1678Cas No. 38990-03-3

Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.

Gelsevirine

Gelsevirine

🥰Excellent
Purity: 97%
Catalog No. TN1678Cas No. 38990-03-3
Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.
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1 mg$198-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97%
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Product Introduction

Bioactivity
Description
Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.
In vitro
Gelsevirine inhibits the dimerization and subsequent activation of STING induced by 2'3'-cGAMP; Gelsevirine also induces K48-linked ubiquitination and degradation of STING, which may be achieved through upregulation and recruitment of TRIM21[1].
Chemical Properties
Molecular Weight352.43
FormulaC21H24N2O3
Cas No.38990-03-3
Smiles[H][C@]12CO[C@@H]3C[C@H]1[C@@]1(CN(C)[C@@]2([H])[C@]1([H])[C@@]31C(=O)N(OC)c2ccccc12)C=C
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

STINGGelsevirine
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