Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regulates chloride transport across the plasma membrane. Additionally, it restores α-sarcoglycan (α-SG) content in mutant cells [1].
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Description | CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regulates chloride transport across the plasma membrane. Additionally, it restores α-sarcoglycan (α-SG) content in mutant cells [1]. |
In vitro | CFTR corrector 12 (compound 17C), at a concentration of 15 μM administered for 72 hours, is capable of restoring α-sarcoglycan levels in cells with the L31P/V247M α-SG mutation [1]. |
Molecular Weight | 436.98 |
Formula | C19H21ClN4O2S2 |
CAS No. | 958941-60-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CFTR corrector 12 958941-60-1 Membrane transporter/Ion channel CFTR inhibitor inhibit