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Geptanolimab
😃Good
Catalog No. T77023Cas No. 2348469-43-0
Alias Genolimzumab, GB-226, CBT-501, CBT501, APL-501, APL501
Geptanolimab (CBT-501) is a humanized IgG4κ monoclonal antibody directed against PD-1 (Programmed Death-1). Geptanolimab functions by competitively blocking the binding of PD-L1 and PD-L2 to PD-1, thereby reactivating T cell activity. Geptanolimab is under development as an immunotherapeutic agent with potential applications in cancer treatment.
Geptanolimab
Geptanolimab
😃Good
Purity: 95%
Catalog No. T77023Alias Genolimzumab, GB-226, CBT-501, CBT501, APL-501, APL501Cas No. 2348469-43-0
Geptanolimab (CBT-501) is a humanized IgG4κ monoclonal antibody directed against PD-1 (Programmed Death-1). Geptanolimab functions by competitively blocking the binding of PD-L1 and PD-L2 to PD-1, thereby reactivating T cell activity. Geptanolimab is under development as an immunotherapeutic agent with potential applications in cancer treatment.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | - | In Stock | |
| 5 mg | $578 | - | In Stock | |
| 10 mg | $913 | - | In Stock | |
| 25 mg | $1,350 | - | In Stock | |
| 50 mg | $1,820 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.5% (SDS-PAGE); 97.6% (SEC-HPLC)
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Product Introduction
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Chemical Properties
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| Description | Geptanolimab (CBT-501) is a humanized IgG4κ monoclonal antibody directed against PD-1 (Programmed Death-1). Geptanolimab functions by competitively blocking the binding of PD-L1 and PD-L2 to PD-1, thereby reactivating T cell activity. Geptanolimab is under development as an immunotherapeutic agent with potential applications in cancer treatment. |
| In vitro | Geptanolimab exhibits high specificity in binding to the PD-1 of Homo sapiens (KD=505 pM) and Macaca mulatta (KD=7.2 nM) [1]. Geptanolimab also enhances T-cell activation in mixed lymphocyte response (MLR) of Homo sapiens and significantly increases the release of IL-2 and IFN-γ [1]. |
| In vivo | Geptanolimab was administered via intraperitoneal injection in MC38 syngeneic tumor model mice, demonstrating significant antitumor activity with a tumor inhibition rate as high as 83% [1]. |
| Synonyms | Genolimzumab, GB-226, CBT-501, CBT501, APL-501, APL501 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDCD1/PD-1/CD279 |
| Molecular Weight | 144.14 kDa |
| Cas No. | 2348469-43-0 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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