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Crovalimab (Synonyms: SKY59, SKY 59, RO7112689, RO 7112689)
Catalog No. T77190 Copy Product Info
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Crovalimab (SKY59; RO7112689) is an Fc-engineered and pH-dependent humanised monoclonal antibody that binds to complement C5 and blocks its cleavage into C5a and C5b, thereby inhibiting MAC formation and intravascular haemolysis. It can rebind to the FcRn receptor under acidic pH conditions and return to the bloodstream, making it suitable for the treatment of paroxysmal nocturnal haemoglobinuria (PNH).
Crovalimab
Copy Product Info🥰Excellent
Catalog No. T77190
Synonyms SKY59, SKY 59, RO7112689, RO 7112689
Crovalimab (SKY59; RO7112689) is an Fc-engineered and pH-dependent humanised monoclonal antibody that binds to complement C5 and blocks its cleavage into C5a and C5b, thereby inhibiting MAC formation and intravascular haemolysis. It can rebind to the FcRn receptor under acidic pH conditions and return to the bloodstream, making it suitable for the treatment of paroxysmal nocturnal haemoglobinuria (PNH).
Crovalimab
Cas No. 1917321-26-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $647 | - | In Stock | |
| 10 mg | $987 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:≥95% (SDS-PAGE); 99.68% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Crovalimab (SKY59; RO7112689) is an Fc-engineered and pH-dependent humanised monoclonal antibody that binds to complement C5 and blocks its cleavage into C5a and C5b, thereby inhibiting MAC formation and intravascular haemolysis. It can rebind to the FcRn receptor under acidic pH conditions and return to the bloodstream, making it suitable for the treatment of paroxysmal nocturnal haemoglobinuria (PNH). |
| In vivo | Method: In cynomolgus monkeys, the pharmacodynamic and pharmacokinetic profiles of a single intravenous dose of Crovalimab (20 mg/kg) and its IgG1 derivative SG115 were evaluated. A multiple dosing regimen (intravenous/subcutaneous) was also used to assess immunological and serological responses. Result: A single dose of Crovalimab inhibited plasma C5 accumulation and sustained complement suppression for up to 8 weeks. SG115 showed a slow clearance rate (1.87 mL/day/kg). The multiple-dose regimen led to increased hemolytic activity, dysphagia, and elevated LDH and ALT levels.[1] |
| Synonyms | SKY59, SKY 59, RO7112689, RO 7112689 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Complement C5 |
| Molecular Weight | ~150 kDa |
| Cas No. | 1917321-26-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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