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1-Methoxycarbonyl-β-carboline

Name: 1-Methoxycarbonyl-β-carboline
Brand: TargetMol
SKU: TN2549
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2549Cas No. 3464-66-2

Alias 1-Methoxycarbonyl-beta-carboline

1-Methoxycarbonyl-β-carboline (1-Methoxycarbonyl-beta-carboline) is an alkaloid from Ailanthus altissima.

1-Methoxycarbonyl-β-carboline

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Purity: 99.70%

Catalog No. TN2549Alias 1-Methoxycarbonyl-beta-carbolineCas No. 3464-66-2

1-Methoxycarbonyl-β-carboline (1-Methoxycarbonyl-beta-carboline) is an alkaloid from Ailanthus altissima.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$189	-	In Stock
5 mg	$479	-	In Stock
10 mg	$662	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,370	-	In Stock
100 mg	$1,850	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.70%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

1-Methoxycarbonyl-β-carboline AI Summary

1-Methoxycarbonyl-β-carboline exhibits multiple bioactivities across various biological systems. It shows antiviral properties against Tobacco mosaic virus U1 (TMV) in Nicotiana tabacum and Nicotiana glutinosa leaves, demonstrating EC50 values of 115000.0 nM and 179000.0 nM in inhibiting viral replication. It also inhibits viral infection and replication by 47.4% to 73.3% at a concentration of 50 ug/mL in combination with quassinoid nigakilactone B or when pre-treated virus suspensions are used. In human HEK-293/NF-kB-luc cells stimulated with TNF-alpha, 1-Methoxycarbonyl-β-carboline inhibits NF-kappaB activity with an IC50 value of 29300.0 nM and more than 50.0% inhibition at 30 uM, indicating potential anti-inflammatory properties through NF-kappaB pathway modulation. In the same cell type, another assay shows inhibition with an IC50 value over 50000.0 nM. Additionally, the compound induces quinone reductase activity in mouse Hepa1c1c7 cells with a 50% response concentration of 30.2 uM. Furthermore, 1-Methoxycarbonyl-β-carboline has demonstrated a modest inhibition rate of 2.9% on PTP1B at 100 uM, suggesting limited effects on this enzyme. It also exhibits neuroprotective effects in cerebral ischemia-induced Mongolian gerbils, significantly improving passive avoidance test values and neuronal survival in CA1 subfields of the hippocampus at a dose of 100 mg/kg, showcasing potential for reducing ischemia-induced brain damage. Overall, these findings position 1-Methoxycarbonyl-β-carboline as a candidate with diverse potential therapeutic applications, including antiviral, anti-inflammatory, and neuroprotective effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Methoxycarbonyl-β-carboline (1-Methoxycarbonyl-beta-carboline) is an alkaloid from Ailanthus altissima.
Synonyms	1-Methoxycarbonyl-beta-carboline

Chemical Properties

Molecular Weight	226.23
Formula	C₁₃H₁₀N₂O₂
Cas No.	3464-66-2
Smiles	COC(=O)c1nccc2c3ccccc3[nH]c12
Relative Density.	1.353 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (397.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (14.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4203 mL	22.1014 mL	44.2028 mL	221.0140 mL
5 mM	0.8841 mL	4.4203 mL	8.8406 mL	44.2028 mL
10 mM	0.4420 mL	2.2101 mL	4.4203 mL	22.1014 mL
20 mM	0.2210 mL	1.1051 mL	2.2101 mL	11.0507 mL
50 mM	0.0884 mL	0.4420 mL	0.8841 mL	4.4203 mL
100 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2101 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc