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Quinacrine mustard hydrochloride

Name: Quinacrine mustard hydrochloride
Brand: TargetMol
SKU: T37031
Rating: 4.5 (1 reviews)

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Catalog No. T37031Cas No. 4213-45-0

Alias Quinacrine mustard HCl

Quinacrine mustard hydrochloride is a fluorescent dye and polycyclic aromatic agent that acts as a mutagen to induce mutants in bacteria.Quinacrine mustard hydrochloride selectively binds to adenine-thymine (AT) base pairs, but not to guanine-cytosine (GC). Quinacrine mustard (hydrochloride) selectively binds to adenine-thymine (AT) base pairs rather than to guanine-cytosine (GC) base pairs, inducing cell cycle arrest at G2/M. Quinacrine mustard (hydrochloride) has been used to label chromosomes for karyotyping by autoradiography.

Quinacrine mustard hydrochloride

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Catalog No. T37031Alias Quinacrine mustard HClCas No. 4213-45-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$148	35 days	35 days
10 mg	$258	35 days	35 days
25 mg	$578	35 days	35 days
50 mg	$1,078	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Quinacrine mustard hydrochloride is a fluorescent dye and polycyclic aromatic agent that acts as a mutagen to induce mutants in bacteria.Quinacrine mustard hydrochloride selectively binds to adenine-thymine (AT) base pairs, but not to guanine-cytosine (GC). Quinacrine mustard (hydrochloride) selectively binds to adenine-thymine (AT) base pairs rather than to guanine-cytosine (GC) base pairs, inducing cell cycle arrest at G2/M. Quinacrine mustard (hydrochloride) has been used to label chromosomes for karyotyping by autoradiography.
In vitro	Quinacrine mustard hydrochloride (0.2 μM; 4h) induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50% in HL-60 cells.[1] Quinacrine mustard hydrochloride (5 μg/ml) can be used for the DNA strain of plant, animal, or human chromosomes.[2] Quinacrine mustard hydrochloride (28 μM) increases the number of mutants that appeared after exposure to bacteria.[3]
Cell Research	Cell experiment: Quinacrine mustard hydrochloride (0.2 μM; 4h) induced cell cycle arrest at the G2+M phase in HL-60 cells and increased the accumulation of cells in this phase by 50%.
Synonyms	Quinacrine mustard HCl

Chemical Properties

Molecular Weight	505.31
Formula	C₂₃H₂₉Cl₄N₃O
Cas No.	4213-45-0
Smiles	Cl.ClC=1C=CC=2C(=NC=3C=CC(OC)=CC3C2NC(C)CCCN(CCCl)CCCl)C1
Relative Density.	1.271g/cm3

Storage & Solubility Information

Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Chloroform: Soluble H2O: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Quinacrine mustard HydrochlorideDye reagent

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