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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

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Catalog No. T39912Cas No. 23669-79-6
Alias 5'-O-DMT-dU

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of dUTP nucleotidohydrolase (dUTPase) in E. coli with a Ki greater than 1 mM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

😃Good
Catalog No. T39912Alias 5'-O-DMT-dUCas No. 23669-79-6
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of dUTP nucleotidohydrolase (dUTPase) in E. coli with a Ki greater than 1 mM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis.
Pack SizePriceAvailabilityQuantity
100 mg$427-10 days
1 mL x 10 mM (in DMSO)$467-10 days
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Product Introduction

Bioactivity
Description
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of dUTP nucleotidohydrolase (dUTPase) in E. coli with a Ki greater than 1 mM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis.
Targets&IC50
dUTPase (E. coli):>1000 μM (Ki)
Synonyms5'-O-DMT-dU
Chemical Properties
Molecular Weight530.57
FormulaC30H30N2O7
Cas No.23669-79-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (188.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8848 mL9.4238 mL18.8477 mL94.2383 mL
5 mM0.3770 mL1.8848 mL3.7695 mL18.8477 mL
10 mM0.1885 mL0.9424 mL1.8848 mL9.4238 mL
20 mM0.0942 mL0.4712 mL0.9424 mL4.7119 mL
50 mM0.0377 mL0.1885 mL0.3770 mL1.8848 mL
100 mM0.0188 mL0.0942 mL0.1885 mL0.9424 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

synthesisnucleotidohydrolaseInhibitorinhibitE. colidUTPasedUTPDNA5'O(4,4'Dimethoxytrityl)2'deoxyuridine5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine5' O (4,4' Dimethoxytrityl) 2' deoxyuridine
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